week 5 extra Q's Flashcards by Hessa Al Salem

Q

Which of the following is expressed by B cells?

a. C3
b. C5
c. C19
d. C49

A

c. C19

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Q

When does Ig heavy chain gene rearrangement start?

a. pre-B
b. pro-B

A

b. pro-B

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Q

Which of the following is the first immunoglobulin to appear on B cell surface?

a. IgM
b. IgG
c. IgD
d. IgA

A

a. IgM

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Q

Which of the following B cells handle blood-borne antigens?

a. B cells in the mucosal system
b. B cells in the BM
c. B cells in the lymph node
d. B cells in the spleen

A

d. B cells in the spleen

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Q

When does Ig light chain gene rearrangement start?

a. pre-B
b. pro-B

A

a. pre-B

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Q

Which of the following helps thymocyte precursors develop in BM?

a. IL-5
b. IL-6
c. IL-7
d. IL-8

A

c. IL-7

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Q

What’s the state of T cells when they enter the thymus?

a. double positive
b. triple positive
c. double negative
d. triple negative

A

d. triple negative

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Q

How do we delete self-reactive T cells?

a. positive selection
b. negative selection

A

b. negative selection

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Q

Which of the following recognizes class I HLA?

a. T cells
b. B cells

A

a. T cells

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Q

Which of the following helper cells help activate macrophages?

a. Th1
b. Th2

A

a. Th1

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Q

Which of the following make holes in bacterial cells?

a. granzymes
b. perforin
c. cytokines

A

b. perforin

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Q

Which of the following is more likely to get a lymphoma?

a. a person with a bacterial infection
b. a person with celiac disease

A

b. a person with celiac disease

chronic stimulation makes more lymphoid cells and that makes mutation more likely

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Q

Which is more common?

a. hodgkins lymphoma
b. non-hodgkins lymphoma

A

b. non-hodgkins lymphoma

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Q

Which of the following is low grade?

a. follicular lymphoma
b. diffuse large B cells lymphoma

A

a. follicular lymphoma

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Q

Which of the following commonly has extranodal involvement?

a. follicular lymphoma
b. hodgkins lymphoma
c. diffuse large B cells lymphoma

A

c. diffuse large B cells lymphoma

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Q

Which of the following is more common?

a. follicular lymphoma
b. hodgkins lymphoma
c. diffuse large B cells lymphoma

A

b. hodgkins lymphoma

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Q

Which of the following is often asymptomatic?

a. follicular lymphoma
b. hodgkins lymphoma
c. diffuse large B cells lymphoma

A

a. follicular lymphoma

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Q

Which of the following has Reed-Sternberg cells?

a. follicular lymphoma
b. hodgkins lymphoma
c. diffuse large B cells lymphoma

A

b. hodgkins lymphoma

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Q

Which of the following occurs due to a translocation of t(14;18)?

a. follicular lymphoma
b. hodgkins lymphoma
c. diffuse large B cells lymphoma

A

a. follicular lymphoma

Q

Which of the following occurs due to a translocation of t(8;14)?

a. follicular lymphoma
b. hodgkins lymphoma
c. burkitts lymphoma

A

c. burkitts lymphoma

Q

Which of the following identifies ALL?

a. auer rods
b. basophilia
c. arthralgia
d. well’s syndrome

A

c. arthralgia

Q

Which of the following is most likely occurs in a chid thats 4 years old?

a. ALL
b. CLL

A

a. ALL

Q

Which of the following is a characteristic of CLL?

a. auer rods
b. basophilia
c. arthralgia
d. well’s syndrome

A

d. well’s syndrome

Q

Which of the following is most likely occurs in 70 y/o man?

a. ALL
b. CLL

A

b. CLL

Which of the following is a characterized by smudge cells? a. ALL b. AML c. CML d. CLL

d. CLL

Which of the following is a characterized by basophilia? a. ALL b. AML c. CML d. CLL

c. CML

Why do patients with MM have a hypercalcemia? a. because the infections they aquire increase bone resprption b. kidneys get damaged and release hormones that increase bone resprption c. IL-6 is activating osteoclasts d. IL-5 is activating osteoclasts

c. IL-6 is activating osteoclasts

Which of these tests is used to determine the type of M protein? a. immunofixation b. serum protein electrophoresis c. urine protein electrophoresis

a. immunofixation

Patient comes in with bone pain and anemia. PBS reveals rouleaux formation. Which of the following is most likely? a. CML b. MM c. AML

b. MM

Which of the following is true about MGUS? a. serum level must be more than 30g/l b. all MM patient had it c. its treated with immunosuppressants

b. all MM patient had it

Which of the following is the most immunoglobulin to be excessivly made in plasma cell myeloma? a. IgM b. IgG c. IgA d. light chain only

b. IgG

Which of the following is mainly diagnosed via biopsy? a. amyloidosis b. MM c. CML d. MGUS

a. amyloidosis

Which type of plasmacytoma tumor is more likely to develop into MM? a. soft tissue tumor b. skeletal tumor

b. skeletal tumor

What is the precentage of people with MGUS that will develop plasma cell neoplasm? a. 10% c. 15% d. 20% d. 25%

d. 25%

patient comes in with renal failure and a spontaneous fracture, Which is most likely? a. amyloidosis b. MM c. burkitt's lymphoma d. MGUS

b. MM

Patient comes in with facial swelling. PBS shows lymphocytes that have vacuoles in them. Which is most likely? a. amyloidosis b. MM c. ALL d. CLL

c. ALL

Which of the following has too many lymphocytes and smudge cells present? a. ALL b. lymphomas c. CLL d. MM

c. CLL

Which of the following has too many follicules in lymph nodes? a. follicular lymphomas b. hodgkins lymphomas

a. follicular lymphomas

Which of the following has RS cells and too few follicules in lymph nodes? a. follicular lymphomas b. hodgkins lymphomas c. CLL d. MM

b. hodgkins lymphomas

Which of the following recruit neutrophils? a. Th1 b. Th2 c. Th17 d. Th18

c. Th17

Which of the following mutations lead to burkitts lymphpma? a. t(14,18) b. t(18,14) c. t(8,14) d. inv(16)

c. t(8,14)

Which of the following mutations lead to follicular lymphpma? a. t(14,18) b. t(18,14) c. t(8,14) d. inv(16)

a. t(14,18)

Which of the following mutations lead to hodgkins lymphpma? a. t(14,18) b. t(18,14) c. t(8,14) d. inv(16)

b. t(18,14)

Immunotyping revealed cells with CD23 on them, which is most likely? a. ALL b. AML c. CML d. CLL

d. CLL | its the activation marker

Patient comes in with infections due to constant leukocytosis and a complaint of fatigue and sensitivity to bugs. Which is most likely? a. ALL b. AML c. CML d. CLL

d. CLL

Which of the following mutations lead to ALL? a. t(14,11) b. t(18,14) c. t(8,14) d. inv(16)

a. t(14,11)