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Blood Module > week 3 extra Q's > Flashcards

week 3 extra Q's Flashcards

1
Q

The life span of platelets is

a. 9 days
b. 10 days
c. 15 days
d. 120 days

A

b. 10 days

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2
Q

Which of the following attaches to the Ashwell-Morell receptor?

a. galactose
b. sialic acid
c. glycogen

A

a. galactose

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3
Q

Which of the following does NOT produce thrombopoietin?

a. liver
b. kidney
c. spleen

A

c. spleen

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4
Q

Which of the following does a 1-day old platelet most likely have on its surface?

a. galactose
b. sialic acid
c. glycogen

A

b. sialic acid

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5
Q

When you get a cut, which of the following will vasoconstrict?

a. the injured blood vessel
b. the rest of the body’s blood vessels

A

a. the injured blood vessel

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6
Q

Weibel palade bodies release which of the following?

a. prostacyclin
b. thromboxane A1
c. thromboxane A2
d. von willebrand factor

A

d. von willebrand factor

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7
Q

Which of the following coagulation factors is made by endothelial cells and the liver?

a. CF VII
b. CF VIII
c. CF IX
d. CD X

A

b. CF VIII

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8
Q

Which hemostasis model is closer to reality?

a. cell-based model
b. waterfall model
c. skyline model
d. victorian model

A

a. cell-based model

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9
Q

Which of the following is the central event of the cell-based model of hemostasis?

a. fibrin formation
b. thrombin formation
c. platelet activation
d. protein S activation

A

b. thrombin formation

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10
Q

Which of the following is the initiator of the extrinsic pathway of hemostasis?

a. coagulation factor IX
b. exposed collagen
c. tissue factor
d. platelet-derived growth factor

A

c. tissue factor

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11
Q

Which of the following crosslinks fibrin monomers?

a. plasmin
b. coagulation factor VII
c. coagulation factor XIII
d. platelet-derived growth factor

A

c. coagulation factor XIII

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12
Q

What’s the function of activated protein C?

a. inhibits coagulation factors Va & VIIIa
b. slows down coagulation process
c. A & B
d. none of the above

A

c. A & B

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13
Q

Which of the following breaks crosslinked fibrin?

a. plasmin
b. coagulation factor VII
c. coagulation factor XIII
d. platelet-derived growth factor

A

a. plasmin

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14
Q

Which of the following is only made by endothelial cells?

a. NO
b. prostacyclin
c. antihaemophilic factor A

A

b. prostacyclin

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15
Q

Which of the following is a fibrinolysis inhibitor?

a. plasmin
b. antiplasmin

A

b. antiplasmin

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16
Q

Which of the following is a vessel wall abnormality?

a. DIC
b. Vitamin K deficiency
c. EDS
d. VWD

A

c. EDS

Ehlers-Danlos syndrome

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17
Q

menorrhagia is a defect in

a. primary hemostasis
b. secondary hemostasis

A

a. primary hemostasis

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18
Q

senile purpura occurs because of a defect in

a. platelets
b. vascularity
c. von willebrand factor
d. coagulation factor 3

A

b. vascularity

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19
Q

BM disease qualifies as which type of platelet defect?

a. qualitative
b. quantitative

A

b. quantitative

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20
Q

describe the platelets in a blood smear of a patient with Immune thrombocytopenic purpura (ITP)

a. microcytic
b. macrocytic
c. normocytic

A

b. macrocytic

larger because the BM is trying to compensate

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21
Q

Which of the following is the most common bleeding disorder?

a. hemophilia A
b. hemophilia B
c. VWD
d. DIC

A

c. VWD

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22
Q

Which type of VWF has no von Willebrand proteins at all?

a. VWF type 1
b. VWF type 2
c. VWF type 3

A

c. VWF type 3

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23
Q

VWF antigen level is normal while its activity is low, which type of VWF is the most likely diagnosis?

a. VWF type 1
b. VWF type 2
c. VWF type 3

A

b. VWF type 2

functionality problem

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24
Q

Which of the coagulation factors is available in the extrinsic pathway?

a. VII
b. VIII
c. IX
d. X

A

a. VII

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25
In which of these diseases is intramuscular bleeding more common? a. VWD b. ITP c. Hemophilia B d. Senile purpura
c. Hemophilia B
26
Which of the following occurs when alpha 2-antiplasmin levels decrease? a. decreased plasmin levels b. more fibrinolysis c. less fibrinolysis
b. more fibrinolysis
27
What occurs to activated partial thromboplastin time (APTT) & prothrombin time (PT) during a coagulation factor deficiency? a. APTT increase & PT increase b. APTT increase & PT decrease c. APTT decrease & PT increase d. APTT decrease & PT decrease
a. APTT increase & PT increase
28
Which of the following is the most likely cause of DIC? a. malignancy b. sepsis c. autoimmune disorders
b. sepsis
29
Which of the following do platelets use to bind to each other? a. glycoprotein 1b b. glycoprotein 2b
b. glycoprotein 2b
30
Which of the following do platelets use to bind to von willebrand factor? a. glycoprotein 1b b. glycoprotein 2b
a. glycoprotein 1b
31
Which of these coagulation factors is prothrombin? a. 1 b. 2 c. 3 d. 4
b. 2
32
Which of these coagulation factors is fibrinogen? a. 1 b. 2 c. 9 d. 10
a. 1
33
Which of these coagulation factors is the fibrin-stabilizing factor? a. 5 b. 7 c. 11 d. 13
d. 13
34
antiphospholipid syndrome may cause thrombus formation in which of the following? a. venous circulation b. arterial circulation c. both
c. both
35
Which of the following is the most common cause of inherited thrombophilia? a. antithrombin deficiency b. protein S c. protein C d. factor V leiden mutation
d. factor V leiden mutation
36
Which of the following diseases results from a glycoprotein 1b defect? a. von willebrand disease b. hemophilia b c. bernard soulier syndrome d. glanzmann's disease
c. bernard soulier syndrome
37
Which of the following is the most common bleeding disorder? a. von willebrand disease b. glanzmann's disease c. bernard soulier syndrome d. hemophilia b
a. von willebrand disease
38
Which of the following diseases results from a glycoprotein 2b defect? a. bernard soulier syndrome b. glanzmann's disease c. von willebrand disease d. hemophilia b
b. glanzmann's disease
39
Which type of von willebrand disease is a qualitative defect? a. type 1 b. type 2 c. type 3
b. type 2
40
Which type of von willebrand disease is autosomal recessive? a. type 1 b. type 2 c. type 3
b. type 2
41
Which of the following diseases is caused by a defect in platelet aggregation? a. bernard soulier syndrome b. von willebrand disease c. hemophilia b d. thrombasthenia
d. thrombasthenia (aka glanzmann's disease)
42
Which of the following diseases is caused by a defect in platelet adhesion? a. hemophilia a b. thrombasthenia c. bernard soulier syndrome d. von willebrand disease
c. bernard soulier syndrome
43
Which of the following transports and stabilizes coagulation factor VIII? a. fibrinogen b. thrombin c. tissue factor d. VW factor
d. VW factor
44
Which of the following releases coagulation factor VIII from VWF? a. fibrinogen b. thrombin c. tissue factor
b. thrombin
45
Which of the following mutations on the FVIII gene causes a more severe result? a. addition b. substitution c. rearrangement d. deletion
c. rearrangement | results in a complete deficiency
46
Which one is more common among the Jewish population? a. hemophilia a b. hemophilia b c. hemophilia c
c. hemophilia c
47
Which of the following inactivate coagulation factors V&VIII? a. NO b. prostacyclin c. protein C d. plasmin
c. protein C
48
An increase in which of the following may cause thrombotic disorders? a. protein C b. protein S c. prothrombin d. antithrombin
c. prothrombin
49
During a coagulation factor 8 deficiency, which of the following times increases? a. partial thromboplastin time (APTT) b. prothrombin time (PT) c. thrombin time (TT)
a. partial thromboplastin time (APTT)
50
A patient has a slow APTT time so the doctor ordered a mixing study. The APTT became normal in the test; which of the following does the patient have? a. factor deficiencies b. factor inhibitors
a. factor deficiencies
51
Which of the following does heparin prolong more? a. partial thromboplastin time (APTT) b. prothrombin time (PT) c. thrombin time (TT)
a. partial thromboplastin time (APTT)
52
Which of the following does hemophilia b prolong? a. partial thromboplastin time (APTT) b. prothrombin time (PT) c. thrombin time (TT)
a. partial thromboplastin time (APTT)
53
Which of the following drugs should be given to a patient with transient ischaemic attacks? a. cyclooxygenase inhibitors b. ticlopidine & clopidogrel c. abciximab
b. ticlopidine & clopidogrel
54
Which of the following drugs is given to a patient for percutaneous coronary intervention? a. cyclooxygenase inhibitors b. ticlopidine & clopidogrel c. abciximab
c. abciximab
55
Which of the following drugs inhibits the ADP dependent pathway? a. cyclooxygenase inhibitors b. ticlopidine & clopidogrel c. abciximab
b. ticlopidine & clopidogrel
56
Which of the following drugs inhibits thromboxane synthesis? a. cyclooxygenase inhibitors b. ticlopidine & clopidogrel c. abciximab
a. cyclooxygenase inhibitors
57
Which of the following drugs has a side effect of bronchospasms? a. cyclooxygenase inhibitors b. ticlopidine & clopidogrel c. abciximab
a. cyclooxygenase inhibitors
58
Which of the following drugs inhibits blocks glycoprotein 2b &3a? a. cyclooxygenase inhibitors b. ticlopidine & clopidogrel c. abciximab
c. abciximab
59
Which of the following drugs should be given to a patient with myocardial infraction? a. cyclooxygenase inhibitors b. ticlopidine & clopidogrel c. abciximab
a. cyclooxygenase inhibitors
60
Which of the following drugs has a side effect of thrombocytopenia? a. cyclooxygenase inhibitors b. ticlopidine & clopidogrel c. abciximab
c. abciximab
61
Which of the following is used to prevent clotting in extracorporeal circulation devices? a. warfarin b. heparin c. low molecular weight heparin d. dabigatran
b. heparin
62
Which of the following is contraindicated during pregnancy? a. warfarin b. heparin c. low molecular weight heparin d. dabigatran
a. warfarin
63
The absorption of which of the following is delayed by food? a. dabigatran b. fondaparinux c. rivaroxaban d. otamixaban
a. dabigatran
64
The absorption of which of the following is increased by food? a. otamixaban b. dabigatran c. rivaroxaban d. fondaparinux
c. rivaroxaban
65
Which of the following causes osteoporosis with long term treatment? a. warfarin b. heparin c. low molecular weight heparin d. dabigatran
b. heparin
66
Which of the following leads to better inhibition of coagulation factor X? a. heparin b. low molecular weight heparin
b. low molecular weight heparin
67
Which of the following is a better drug to give a patient with massive pulmonary embolism? a. heparin b. low molecular weight heparin
b. low molecular weight heparin
68
Which of the following is antithrombin III dependent? a. dabigatran b. otamixaban c. fondaparinux d. rivaroxaban
c. fondaparinux
69
Which of the following is a prodrug? a. dabigatran b. fondaparinux c. rivaroxaban d. otamixaban
a. dabigatran
70
Which of the following only acts on fibrin bound plasminogen? a. streptokinase b. urokinase c. alteplase
c. alteplase | no systemic fibrinolysis
71
Which of the following is a coagulation factor 2 inhibitor? a. rivaroxaban b. otamixaban c. dabigatran d. fondaparinux
c. dabigatran
72
Which of the following is an endogenous protease? a. streptokinase b. urokinase c. alteplase
c. alteplase
73
Which of the following does the schilling test measure? a. iron b. hematocrit c. vitamin b12 d. hemoglobin
c. vitamin b12
74
Which of the following is concluded when the schilling test with IF results in a corrected reading? a. pernicious anemia b. patient not eating c. bacterial overgrowth
a. pernicious anemia
75
Which of the following diseases cause RBC destruction only in the spleen? a. sickle cell anemia b. autoimmune hemolytic anemia c. spherocytosis d. Paroxysmal nocturnal hemoglobinuria (PNH)
c. spherocytosis
76
A thrombus in the venous system is most likely caused by a. stasis b. endothelial injury
a. stasis | arterial thrombus formation= endothelial injury
77
Which of the following leads to forward propagation? a. arterial thrombus b. venous thrombus
b. venous thrombus | arterial thrombus= backward propagation
78
where is VWF stored? a. endothelial cells b. megakaryocytes c. dense granule d. alpha granule
d. alpha granule
79
Which of the coagulation factors is vitamin K independent? a. CF1 b. CF2 c. CF9 d. CF10
a. CF1
80
Which of the following cleaves VWF multimers? a. ADAMTS11 b. ADAMTS12 c. ADAMTS13 d. ADAMTS14
c. ADAMTS13
81
Which of the following hemostatic pathways can occur outside of the body? a. extrinsic b. intrinsic c. common
b. intrinsic | Blood is clotted in a plain tube due to factor 12 activation
82
Which of the following is a fibrinolysis inhibitor? a. protein C b. protein S c. TFPI d. TAFI
d. TAFI (Thrombin-Activatable Fibrinolysis Inhibitor) | TFPI= Tissue Factor Pathway Inhibitor
83
Which of the following is used to diagnose a coagulation factor deficiency? a. factor assay b. isolated APTT prolongation c. isolated PT prolongation d. isolated TT prolongation
a. factor assay
84
Antithrombin is a major inhibitor of which TWO of these coagulation factors? a. CF8 b. CF9 c. CF10 d. CF11
b. CF9 & c. CF10
85
Which of the following is inherited in an autosomal recessive fashion? a. protein C deficiency b. protein S deficiency
b. protein S deficiency
86
Which of the following deficiencies may lead to the development of warfarin-induced skin necrosis? a. protein C deficiency b. protein S deficiency c. antithrombin deficiency d. prothrombin gene mutation
a. protein C deficiency
87
Which of the following results from a mutation of 3'UTR? a. increase activity of factor V leiden b. protein C becomes inactive c. prothrombin mRNA becomes stable d. DNA of antithrombin becomes more active
c. prothrombin mRNA becomes stable
88
Which of the following mutations causes a stabilization on the mRNA of prothrombin? a. 3'UTR b. 5'UTR c. CAAT mutation d. BCR-ABL
a. 3'UTR

Blood Module (6 decks)

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