week 4 pharm Flashcards
antipsychotics & mood stabilizers
Lithium
*range 0.5 to 1.2 mEq/L
- inverse relationship w sodium
- first line of treatment for acute mania & depression
-prevents manic & depressive episodes - mood stabilizer that prevents mood cycling (3-6 weeks)
*interacts w NSAIDS & diuretics & anticholinergics & antidepressants
expected side effects of Lithium
sedation
acne
nausea
excessive thirst
hand tremors
weight gain
early lithium toxicity
1.2 - 1.5
* hold med & call dr
n/v/d
muscle weakness
slurred speech
advanced lithium toxicity
> 1.5
-excess sweating
-vomiting
-diarrhea
EEG changes
-hand tremor
- muscle hyper-irritability
- GI upset
- confusion
-incoordination
*stupor
*blurrred vision
*affects KIDNEYS
**treated w normal saline bolus
long term effects of Lithium
hypothyroidism - goiter
kidney dysfuction
weight gain
*assess levels every 6 months
Anticonvulsants
1st line of treatment mood stabilizer – bipolar mania, hypomania, mixed states, cycling
*ValPROic Acid
*DivalPROex
*ValPROate
Expected side effects of valPROic Acid
*anticonvulsant
tremor
sedation
GI pain
hair loss
weight gain
blood dyscarias – anemia & thrombocytosis
hepatotoxicity
pancreatitis
*taken in patients w kidney dysfunction
lithium affects ____ buut anticonvulsants affect _____
lithium = kidneys
anticonvulsants = liver
anticonvulsant therapeutic levels & toxicity symptoms
*ValPROic Acid
*DivalPROex
*ValPROate
85 - 125 ug/mL
toxic = intentional overdose
- ataxia (loss of body movement)
- confusion
- somnolence
-coma
Carbamazepine
anticonvulsant
treats bipolar disorder, rapid cycling, mixed states
treats & prevents acute mania
*MONITOR FOR RASHES
Adverse effects of Carbamazepine
*anticonvulsant = mood stabilizer
- hyponatremia & fluid overload
- decreases effectoveness of birth control
- blood dyscrasias
- hepatic disease
RASH
*fatigue & nausea
*diplopia (double vision)
*ataxia
Lamotrigine treats ___ & adverse effects
**anticonvulsant = bipolar depression–acute &maintenance
- monitor for FEVER = aseptic meningitis
- lower birth control effectiveness
- Steven Johnsons
Anxiolytics are
Benzodiazepenes = Clonazepam & Lorazepam
given when concerned about heart or delirium
adjunctive agents for acute mania & psychomotor agitation
second - generation antipsychotics are best for
non-compliance for acute mania, bipolar depression, & their prevention
first-generations antipsychotics
Chlorpromazine
Loxapine
Fluphenazine
Haloperidol
- treat POSITIVE symptoms
- used less = adverse effects