Week 4 Flashcards

1
Q

Development dysplasia of the hip

  • description
  • dx
  • tx
A
  1. Femoral head doesn’t sit completely inside acetabulum
    - 2ndary to capsular laxity and mechanical factors

2a) Ortolani’s test
- elevate hip and abduct of femur
- hip is reducible

b) Barlow’s test
- adduct and depress femur
- hip is dislocatable out the back

c) Ultrasound

  1. Achieve and maintain early, concentric reduction
    - pavlik harness
    - closed and open reduction
    - osteotomies
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2
Q

Slipped capital femoral fracture

  • description
  • epidemiology
  • clinical presentation
  • tx
A
  1. Slip through the growth plate
    - The femoral head remains in the acetabulum, the neck is displaced anteriorly and externally rotates
  2. Seen most commonly in
    - Adolescent, obese, African American boys
  3. Presentation
    • Limp
    • Externally rotated gait
    • Obligatory external rotation with hip flexion • Decreased hip internal rotation
    • Hip, thigh
    • Knee pain - referred from obturator nerve
  4. Stick a pin going through head and neck until growth plate heals and solidifies
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3
Q

Femoral shaft fracture tx

A
  • Restore limb length
  • Restore alignment
  • Restore rotation
  • use intramedullary nail
  • early stabilization important to reduce blood loss and fat emboli
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4
Q

Which vessels provide blood to head of femur

A

Circumflex femoral vessels and obturator artery

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5
Q

AVN

  • what happens
  • most common non-traumatic causes
  • imaging
  • tx
A
  • occlusion of vessels leading to bone necrosis and cartilage collapse
  • alcoholism and steroid use
  • X-ray + MRI (for earlier stages)

TREATMENT

i. Early stages
1. Bisphosphonates
2. Anticoagulants
ii. Core decompression
1. Unpredictable outcome
iii. Rotational osteotomy
1. Cut and rotate proximal femur towards a better weight bearing area of bone
iv. Vascularized fibular strut grafting
v. Hip arthroplasty
1. Do this if there is an area of collapse

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6
Q

Greater trochanteric bursitis

  • presentation
  • tx
A
  • pain right over the greater trochanter
  • bursitis b/w greater trochanter and IT band

TX

  • activity mods
  • anti-inflammatories
  • physical tx -> stretches to give bursa more room
  • cortisone injection -> to help w/ PT
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7
Q

Wear and tear arthritis =

  • what increases risk
  • presentation in the hip
  • physical exam
  • imaging
  • tx
A

osteoarthritis

-obesity, age, FH

  • Stiffness in the hip
  • Pain “flares”
  • Groin pain - always check hip w/ groin pain
  • Limp

PHYSICAL EXAM
• Decreased range of motion
• Internal rotation most often restricted
• Obligatory external rotation of the hip when flexed
• Limp
• Reproducible groin pain

XRAYS
• Joint height narrowing
• Sclerosis 
• Cystic formation 
• Osteophytes

Tx

  1. Start w/ activity mods and ice
  2. Anti-inflammatory
  3. Cortisone injection
  4. Only “cure” is total hip replacements
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8
Q

Hip fracture

-younger vs older patients

A

i. In younger patients -> preserve bone and cartilage as much as possible

ii. Older -> harder to heal so reduction and fixation on some and total hip replacements on others
iii. In older individuals -> very high (30-50%) 3 month mortality rate

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9
Q

Unique aspect of seronegative spondyloarthropathies

A

Enthesitis -> inflammation of insertion of ligament or tendon into the bone

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10
Q

Key feature to separate mechanic back pain from inflammatory

A

inflammatory gets better w/ exercise

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11
Q

Progression of anklylosing spondylitis

A

Bilat SI inflammation w/ pain in gluteal area -> ossification of spinal ligaments (bamboo spine)

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12
Q

Reactive arthritis presentation

A

asymmetric inflammatory oligoarthritis that develops 1-4 weeks after a nongonococcal urethritis or an infectious diarrhea; usually involves joints in the lower extremities

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13
Q

Triad for Reiter’s syndrome

A
  1. Nongonococcal urethritis
  2. Uveitis/Conjunctivitis
  3. Arthritis of large joints (inflammatory)
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14
Q

Organisms associated with Reactive arthritis

A

U CCSSY

Ureaplasma

Campylobacter
Chlamydia
Salmonella
Shigella
Yersinia
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15
Q

Other key manifestation unique to reactive arthritis

A
  1. Oral ulcers
  2. Keratoderma blenorrhagica—erythematous scaly hyperkeratotic skin lesions on palms and soles
  3. Circinate balanitis—red scaly area on the glans penis with a gray, serpiginous annular edge that spreads outwards in phases

IMAGING
-asymmetric non-marginal jug handle syndesmophytes

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16
Q

Unlike in RA, which phalangeal joints can be involved with psoriatic arthritis?

A

DIP

dactylitis w/ pitting for finger nails

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17
Q

Which type of arthritis with PA?

A
  • most commonly asymmetric oligoarthritis

- can also be poly like RA

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18
Q

Arthritis mutilans

A
  • associated with PA or poorly managed RA

- complete joint erosion

19
Q

Imaging finding with PA

A

Pencil in a cup sign -> central erosion

Followed by ankylosis

Spondyloarthropathy -> comma shaped

20
Q

Key points about paget’s disease

  • most common location
  • number of bones involved
  • uni or bi lateral
A
  • pelvis
  • polyostotic
  • unilateral
21
Q

T1 vs T2 MR imaging

A

T1 -> bone, vessels, nerve (any soft tissue)

T2 -> fat suppression (appears dark)

  • so fluid can show up bright
  • good for looking at edema
22
Q

3 general fractures

A
  1. Traumatic
  2. Stress
    A) Fatigue - abnormal stress across normal bone
    B) Insufficiency - normal stress across abnormal bone
23
Q

1 cause of AVN

A
  • trauma

- most occur at head of femur

24
Q

Radiology signs of quadriceps tendon rupture

A

fat pad displaced anteriorly

->edema in suprapatellar bursa

25
Key radiology signs of ACL tear
Acute injury with joint effusion on X-ray | -fat pad displaced anteriorly
26
Anakinra - generic - MoA - side effects
o IL-1Ra o Endogenous antagonist of IL-1 o Binds to receptor but no signaling ensures o IL-1 is produced by RA synovium o Drug didn’t work too well o Receptor antagonist was only occupying receptor for a brief period of time o Also increased incidence of bacterial infections o Additional IL-1 antagonists are being studies • Canakinumab and rilonacept
27
TNF inhibitors - categories + drugs - side effects - contraindications
1. Soluble TNF receptor - Etancercept 2. mAb - Adalimumab - fully humanized -> high affinity - infliximab - chimeric SIDE EFFECTS - increased risk of infection - reactivation of TB CONTRAINDICATIONS - pregnant/nursing women - recent live virus vaccine (e.g. HSV for shingles) - allergy to mouse/hamster proteins
28
Abatecept (Orencia)
- CTLA4 w/ IgG1 | - blocks activation of T-cell
29
Tocilizumab (Actemra)
IL-6 inhibitor • Blocking this will push naïve T-cell towards the T-reg pathway which tones down the immune response ADVERSE EFFECTS • Serious infectious adverse events are a concern o Risk increases w/ time • Cause neutropenia as well but not progressive but improves over time • Elevates LFT but not a major issue • Can raise LDL • Diverticuli • Can increase metabolism of some drugs by enhancing CYP450
30
Rituximab (Rituxan)
``` • Targeting B-cells • Anti-CD20 o Not present on the progenitor cells • Rituximab targets this marker o Induces apoptosis of B-cells ``` Adverse effects • Inc risk for infections • Allergic rxns
31
BAFF (BLys)
• Target B-lymphocyte stimulating hormones • BAFF promotes B cell maturation and survival • BAFF also synergizes w/ IL-6 in TH17 creation • Anti-BAFF agents are in trial – Benlysta -Human mAb -Tested in lupus patients -Significant improvement over conventional tx
32
Classify the primary lesions
1. Flat - macule/patch 2. Raised - papule/plaque - nodule - tumor 3. fluid filled - vesicles/bulla - pustules -> fulled w/ neutrophils/eosinophils
33
Translucent lesions on skin - think?
- BCC | - eccrine neoplasms -> very translucent
34
Distribution of Herpes Zoster lesion
Dermatomal
35
Arrangement/pattern of HSV
grouped vesicles on an erythematous base
36
linear pattern of lesion due to?
external sources such as poison ivy
37
Annular morphology - def - example
-ring with central clearing Tinea corporis (ringworm)
38
Pityriasis rosea presents with what type of lesion?
Oval
39
Round or nummular lesions - description - cause
- coin shaped lesions | - discoid lupus or nummular dermatitis
40
Hemorrhagic crust - which layer of skin - risk for
- past the epidermis | - risk for scarring
41
Lab to look at scabies
Mineral oil prep of scraping
42
Lab to look at fungal infection
KOH prep - margin scaling of lesion
43
Fissure on the lower leg think
Eczema craquele
44
Umbilicated lesion - description - example
- central depression or dell | - Molluscum