week 4 Flashcards
is bipolar disorder chronic and a life threatening illness?
yes
Explain how bipolar disorder “cycles”
pts with bipolar disorder cycle through different periods of normal functioning, mania, hypomania, or periods of depression.
What are the ranges of symptoms on a continuum of bipolar disorder?
mania
depressive symptoms
mixed (Both)
at what age does bipolar disorder usually onset?
18
can bipolar disorder be induced by menopause?
yes
which gender does bipolar 1 disorder effect more?
both male and female equally
which gender does bipolar 2 disorder effect more?
female
Why does bipolar disorder occur? What are the causes?
- genetics
- neurobiological factors
- neuroendocrine factors
- neuroanatomical factors
- environmental and psychological influences
- cultural considerations
What are neuroanatomical factors of bipolar disorder?
- pts have less gray matter volume
- smaller amygdala
what are some examples of neuroendocrine factors of bipolar disorder?
hormones play a BIG ROLE
Women who have bipolar disorder have worse PMS symptoms
What can lead to a relapse of bipolar disorder?
sleep
what are some examples of environmental and psychological influences in bipolar disorder?
- stress
- interpersonal conflict
- poor sleep
What three diagnoses do pts with bipolar 1 disorder cycle between?
- at least one episode of mania
- major depressive disorder
- possible psychosis
Does a pt with bipolar disorder 1 experience psychosis? What do they experience with psychosis?
yes, delusions or hallucinations
in a pt with bipolar disorder 1, and experiencing psychosis, what “kind” of delusions do they experience?
- grandeur delusions
- paranoid delusions
What are signs of mania in bipolar 1 disorder?
- euphoria or agitation
- irritability or anger
- increased energy
- rapid speech
- flight of ideas
- delusions of grandeur
- decreased need for sleep
Define mania
when someone has a persistent or elevated or irritable mood accompanied by these changes in these activities or energy
What is KEY to know if someone is going through a manic episode?
Decreased need for sleep
they won’t sleep for days or weeks
What is the key difference between bipolar 1 and bipolar 2 disorder?
Bipolar 1 has MANIA
Bipolar 2 has HYPO mania
Difference between mania and hypomania?
someone with mania CANNOT function but someone with HYPOmania can function and can sleep
What do pts with bipolar disorder 2 typically cycle between?
- at least one period of mania
- one or more periods of depression
What are some depressive characteristic s of a pt with bipolar 2 disorder?
1.hoplessness/ sadness
2. altered sleep
3. appetite and weight changes
4. inability to concentrate
5. inability to make decisions
6. suicidal thoughts
what do pts with bipolar2 disorder not experience that is KEY in bipolar 1?
no psychosis
no hallucinations
no delusions
Hypomania or Mania
EX: Treats everyone with familiarity and confidentiality; often borders on crude
hypomania
hypomania or mania
EX: Becomes inappropriately demanding of peoples attention, and intrusive nature repels others
mania
Hypomania or Mania
EX: May have a voracious appetite, eat on the run, or gobble food during brief periods
hypomania
hypomania or mania
EX: no time to eat-too distracted and disorganized
mania
What “type” of foods are the best option for Mania pts?
finger foods because they don’t think too eat
Explain delirious mania
happens acutely, life threatening, and happens quickly and suddenly.
1. disoriented
2. psychosis
3. catatonia
What is cyclothymic disorder
When they alternate between hypomania and depression
they have multiple hypomania episodes
If someone is showing symptoms of mania, what are the PRIORITIES to find in your assessment?
- dehydration
- cardiac status
- sleep
- safety
PHYSIOLOOGICAL PRIORITIES
We want to make sure they aren’t using up too much energy that leads up to these issues
What can lead to cardiac collapse?
not getting enough sleep
If a patient is impulsive what is a priority?
Ex: blurting out words or making certain gestures
safety safety safety
What is a “good” amount of sleep for someone with mania?
4-6 hours of sleep
how often should you get vitals for someone with mania?
multiple times during the day
*attempt like around every hr or at least the HR
Would competitive activities be optimal for someone with bipolar disorder/mania?
Naurrrrr
these individuals are very competitive, they will deplete their energy
distarct them to something more solitary
What are some interdisciplinary treatments for those with Bipolar disorder?
- pharmacotherapy
- psychosocial support
- CBT
- interpersonal and social rhythm therapy
- family therapy
- support groups
are those with bipolar disorder able to deal with change well?
Naurrrrr so interpersonal and social rhythm therapy help them cope with change.
change may induce manic episodes
What are the pharmacological therapies?
- Mood stabilizers
- anticonvulsants
- anxiolytics
- second gen antipsychotics
- ECT
What is lithium used for?
Used as a mood stabilizer and is used as the first line of tx
What disorders does lithium target/help treat?
- acute mania
- acute BP depression
- Prevention of manic and depressive episodes
How long does it take lithium to have a full response?
3-6 weeks
What is a contraindication of lithium?
- NSAIDS
- caution with diuretics, lithium level might go up
let’s say someones sodium level goes down, what happens to the lithium level? What does this increase the risk for?
Sodium DOWN
Lithium UP
(Vice versa)
INCREASES RISK FOR LITHIUM TOXICITY
What is the therapeutic level for lithium?
0.5-1.2 mEq/L
does a level of 1.2-1.5 lithium level indicate toxicity?
No, its not toxic buuuuut its a red flag
What are the common EXPECTED side effects of someone taking lithium?
- fine hand tremors
- polyuria, mild thirst
- nausea
- weight gain
- sedation
- acne
Therapeutic level for ADVANCED signs of lithium toxicity
1.5-2
therapeutic level for SEVERE lithium toxicity
2+
If the therapeutic level of lithium is between 1.2-1.5 what should you do?
- Hold medication
- Call doc
- Get the dosage reevaluated
usually if the pt skips a dose that’s enough to get them to a safer range
If the therapeutic level is between 1.2-1.5, what symptoms may the pt experience?
- n/v/d
- slurred speech
- muscle weakness
What level is the KEY to know if the lithium level is toxic?
anything above this level is toxic
ANYTHING ABOVE 1.5 IS EL TOXICOOOOO
What are some symptoms someone will experience in advanced signs of toxicity? 1.5-2mEq/L
- coarse hand tremor
- GI upset
- Mental confusion
- Muscle hyper-irritability
- EEG changes
- incoordination
What is usually the tx for someone who has a lithium lab level of 1.5-2?
Give a saline bolus to bring the lithium level down
(Giving them sodium to bring that lithium level down)
If the lithium level is 2+, which is severe toxicity, what tx do they usually need to get rid of the lithium?
dialysis to get rid of the lithium in the body because it affects the kidneys at this point
What are some symptoms a pt will experience with lithium levels of 2+?
- ataxia
- Serious EEG changes
- Blurred vision
- clonic movements, seizures
- Stupor
- Coma
- Death
What are some general long term side effects of lithium?
- HYPOthyroidism, goiter
- kidney dysfunction
When someone is taking lithium, what do we usually want to get a baseline test of?
Baseline thyroid function test because they are susceptible to HYPOthyroidism
Since lithium can affect the kidneys, what do we want to monitor?
BUN and creatinin levels
What are commonly seen anticonvulsants?
all the same med
(HINT)
2 Vaginas
2 Dicks
= orgasms looks like SEIZURES lol
- Valproic acid
- Depakote
- Divalproex
- Valproate
if you see that the pt has a valproic acid level but you dont see them taking valproic acid what does that mean?
Valproic acid is the lab draw so their probably taking depakote or divalproex
What are anticonvulsants usually effective in tx of?
- Bipolar mania
- hypomania
- mixed states
- Rapid cycling
What are the side effects of anticonvulsants?
(HINT mnemonic)
Grace
Tried
Sucking
His
Weiner
buuuut didn’t like his enlarged prostate from his…
B
P
H
G: GI pain
T: Tremors
S: Sedation
H: Hair loss
W: Weight gain
B: Blood Dyscrasias
P: Pancreatitis
H: Hepatotoxicity
Since anticonvulsants can have a side effect of blood dycrasias, what should we monitor?
always monitor CBC
Why would anticonvulsants be the first line of tx for someone with kidney issues?
Because its Hepatotoxic not Nephrotoxic
Lithium can cause kidney dysfunction… so for someone who has kidney issues give them an anticonvusant for someone with liver issues give them lithium
What is the therapeutic level for anticonvulsants?
85-125
anticonvulsant toxicity symptoms
ataxia
confusion
somnolence
coma
TX for anticonvulsant toxicity
stop medication
give fluids
What is carbamazepine?
anticonvulsant