week 3 Flashcards
Are men or women more likely to self medicate? (ex: substance abuse etc)
men
Is depression considered a normal part of aging?
No
What causes depression?
triggers
genetics
biochemical
learned helplessness
cultural
Explain the “learned helplessness” phenomena
anxiousness or so many overwhelming factors that eventually turns into “well, I don’t even care anymore”.
What are the two kinds of depressive disorders learned in class?
- major depressive disorder
- persistent depressive disorder
What “state” is someone in when they have major depressive disorder?
constant state of unhappiness
What is a KEY feature of someone with Major depressive disorder?
loss of pleasure or not interested in things they used to enjoy
What are symptoms of Major Depressive Disorder?
- guilt
- appetite changes
- suicidal thoughts
- psychomotor retardation
- interest lost
concentration diminished - energy decreased
- Sleep disturbance (includes insomnia or hypersomnia)
What are symptoms of persistent depressive disorder?
- Hard to distinguish between person’s usual pattern of functioning
- daytime fatigue
- irritable
- able to function but not optimally
- eating too much or too little
- pessimistic thinking
- low self-esteem
What are two medical diagnoses that can mimic depression symptoms?
- vitamin D deficiency
- HYPOthyroidism
What are things you will look for in an assessment on a pt with depression?
- physical exam
- recognizing the common symptoms
- depression scale
- hx of previous episodes and coping skills
- support systems
- cultural factors
what are common symptoms to look for in a pt with depression?
- mood and affect
- cognition and thought content
- physical changes
- suicide and homicide assessment
What 3 questions do you ask in a suicide assessment?
- Do you have thoughts on harming yourself?
- what is your plan
- determine if they have the means to carry out that plan
what is the main difference between a suicide assessment and a homicide assessment?
Is there is a specific target they want to harm or anyone who walks into the room
What is the depression scale called?
PHQ-9
How is the PHQ-9 useful?
is not used to diagnose someone with depression but refer the pt to somewhere else for further eval
What is ALWAYS the priority for someone with depression?
safety safety safety
what therapeutic technique works BEST for someone who is depressed?
therapeutic silence
What are the interdisciplinary treatments for depression?
- milieu therapy
- psychotherapy
- mindefullness-based cognitive therapy
- group therapy
What is the first line of treatment?
CBT: cognitive behavior therapy
modifies any dysfunctional thoughts
what is mindfulness-based cognitive therapy
a form of CBT that is basically meditation
What are the different types of antidepressants?
SSRIs
SNRIs
Trazadone
TCAs
MAOIs
Buproprion
When it comes to antidepressants, they have black box warning that there is an increased risk of suicide when taking the medication, why?
antidepressants target mood symptoms and do not target suicidal ideation. SO if the pt has a changed mood and they have more energy they will have the energy to carry out that suicide.
INCREASED RISK OF SUICIDE
you want to make sure that when someone starts an antidepressant that you’re checking up on them
List the 5 SSRIs
- Citalopram
- Escitalopram
- Fluoxetine
- Paroxetine
- Sertraline
What are SSRIs useful for treatment in?
- Depression with anxiety
- Panic disorder
- PTSD
- OCD
- Bulimia
What are the side effects of SSRIs?
- Sleep disturbance
- Sexual dysfunction
- Tension headaches
- Reduced appetite
- hyponatremia (Headache is a sign of hyponatremia)
- Rash/SJS
How long does it take SSRIs to take FULL effect?
2-3 WEEKS for full effect
What does SSRI stand for and how does it work?
Selective Serotonin Re-uptake inhibitor
Prohibits the re-uptake of serotonin so there’s more serotonin available in the brain
**the higher the dose the higher risk there are for Serotonin Syndrome **
Signs of Serotonin Syndrome
hint SHIVERS
- S shivering
- H hyperreflexia
- I increased temp
- VS vital sign instability
- E Encephalopathy
- R restlessness
- S Sweating
- Abdominal pain
Why would you NOT want to give two antidepressants at the same time?
increased risk for serotonin syndrome
If a pt with ulcers or a GI bleed is taking antidepressants what are they at risk for?
higher risk for another GI bleed
What medication do you NOT want to give SSRIs with?
warfarin!
because of the increased bleeding tendencies
What are the 4 SNRIs?
- Venlafaxine
- Desvenlafaxine
- Duloxetine
- Levomilnacipran
What do SNRIs inhibit?
serotonin and norepinephrine
SNRIs are useful in treatment of what disorders?
Major depressive disorder and anxiety disorder
What is trazodone usually prescribed for?
Trazodone is usually prescribed for sleep, but it is classified as an anti-depressant.
Can trazodone be given with SSRIs?
yes but mostly targets sleep
What does trazodone block? What should be be mindful of when giving someone trazodone?
it blocks serotonin so we want to be mindful in looking for symptoms of serotonin syndrome
What is an adverse effect of trazodone?
Priaprism
painful erect dickkkkk
What are the 4 Tricyclics? (TCAs)
- Amitriptyline
- Doxepin
- Imipramine
- Nortriptyline
How long does it take for TCAs to take FULL effect?
4-8 weeks
What anticholinergic side effects do TCAs have?
- Dry mouth
- Blurred vision
- Tachycardia
- Constipation
- Urinary retention
- Esophageal reflux
- Photophobia
- Sexual dysfunction
What anticholinergic effects of TCAs is considered a medical emergency while taking this medication?
Constipation
Urinary retention
Which medication is known to be very cardiotoxic?
Tricyclics (TCAs)