Week 4 Flashcards
develops if the supply of coronary blood cannot meet the demand of the myocardium for oxygen and nutrients.
myocardial ishmeia
most common cause of myocardial ishmeia
atherlosclerosis
chest pain caused by myocardial ischemia.
Angina pectoris
substernal chest discomfort, ranging from a sensation of heaviness or pressure to moderately severe pain
angina pectoris
Pain may radiate to the neck, lower jaw, left arm, and left shoulder
-Pallor, diaphoresis, and dyspnea
- relieved by rest and nitrates;
angina pectoris
-gradual luminal narrowing and hardening of the arterial walls
-associated with physical exertion or emotional stress.
stable angina
-transient ischemia of the myocardium that occurs unpredictably and almost exclusively at rest.
Prinzmetal angina (also called variant angina)
when does variant angina occur
at rest and randomly
Management of Reversible Ischemia
-increase delivery of oxygen
-omprove coronary artery blood flow and to -reduce myocardial oxygen consumption.
Myocardial Ischemia treamtnet
- Nitrates (nitroglycerin)-
- Beta Blockers-
- Calcium channel clockers (CCBs)
improve coronary blood flow and reduce myocardial demand by decreasing peripheral vascular resistance
- Nitrates (nitroglycerin)-
diminish catecholamine induced elevations of heart rate, myocardial contractility, and blood pressure
- Beta Blockers-
decrease the influx of calcium into myocardial cells and vascular smooth muscle cells
-modify SA and AV nodes
calcium channel blockers (CCBs)
procedure whereby stenotic (narrowed) coronary vessels are dilated with a catheter
Percutaneous coronary intervention (PCI)
atherosclerotic plaque has ruptured, and infarction may soon follow.
unstable angina
-occludes the vessel for no more than 10 to 20 minutes
-new onset angina, angina that is occurring at rest, or angina that is increasing in severity or frequency.
unstable angina
Unstable angina is precurssor
Infarction happens if last more than 20 mins
Unstable angina is precurssor
Infarction happens if last more than 20 mins
Subendocardial myocardial infarction
involves only one layer of the heart
the mysocradium
Transmural MI
-effects all 3 layers of heart
Transmural infarction usually causes marked elevations in the ST segments on ECG.
-immediate intervention
Cardiac cells can withstand ischemic conditions for about ___–minutes before cellular death takes place.
20
when ischemic injury is exacerbated once blood flow is restored
Reperfusion Injury
-involves the release of toxic oxygen radicals, calcium flux, and pH changes
-mitochonrdia death
first symptom of acute MI is
usually sudden, severe chest pain
heavy and crushing, such as an“elephant sitting on my chest.
-radiate to the neck, jaw, back, shoulder, or left arm.
myocardial infarction
most commonly occluded artery and most associated with death after MI
left anterior descending artery (LAD)