Week 4 Flashcards
Regions in the brain that are activated by substances
Basal Ganglia – motivation, habits, routines
* Repeated Exposure = ↓ sensitvity = Tolerance)
Amygdala - anxiety, irritability, and unease
* Withdrawal feelings = Motivation to seek out drug
PFC - plan, solve problems, make decisions, and exert self-control over impulses
* reduced impulsive control, not done in adolescents so at risk for substances
The structures involved in the reward system
Ventral Tegmental Area (VTA)
Nucleus Acumbens
Amygdala
Hippocampus
Prefrontal cortex
Reward system: VTA
- Dopamine-rich nucleus that mediates reward system
- Located in midbrain, next to the substantia nigra
- Sends dopamine to the nucleus accumbens, amygdala, hippocampus,and prefrontal cortex. –> START of system
- ↑ VTA pathways – implicated in OCD
Reward system: Nucelus Acumbens
Involved in all motivationally-relevant stimuli –> both rewarding or aversive.
Interface between motivation + action (connection to caudate nucleus)
Reward system: Amygdala
Happiness & Enjoyment
Anxiety, irritability, and unease - Withdrawal feelings = Motivation to seek out drug
helps you like soemthing, and not .ike something
Reward system: hippocampus
- Memory and learning
Reward system: Prefrontal cortex
Reasoning, problem-solving, impulse control, creativity, perseverance
What are the two dopamine pathways
Mesolimbic and mesocortical
Mesolimbic
route between VTA, Nucleus accumbens, and
limbic system (hippocampus & amygdala)
* Key Pathway in Pleasure and Reward.
* Substance use
EMOTIONAL aspect of wanting to use a substance again
Mesocortical
route between VTA/Nucleus accumbens and
PFC.
BEHAVIORAL aspect of going adn getting drug
What hormone is released in stress and what does it do (substance use)
cortcotropin-releasing hormone (CRH) is released
* Strengthens the Amygdala (strengthens emotional response)
* Weakens the hippocampus & prefrontal cortex (hippocampus: don’t want to remember)
You are then at greater risk for substance use:
* Negative emotional state
* Lack of executive control =↑ risk of relapse
* Memory of relief/cravings
Substance use and stress research studies
- 1/3 adol with reported abuse/neglect will develop a SUD before 18.
- 2-4x of those with PTSD developing chemical dependencies.
- SGM across lifespan = ↑ risk of TUD and AUD + homelessness = 5x
- COVID-19 = ↑ 23% increase in AUD
Is stress a universal construct?
Yes and no
Asian show more physical symptoms of stress
Americans report emotional feeling of stress
East asiains more stress with relationships
Europeans more stress around indivdiual
stuff
Neural effects of SUD
Cocaine, pathological gambling, nicotne = ↓
gray matter in PFC
Leads to hypofrontality: decreased PFC activity
–> see this in Schizophrenia
Schizophrenia:
- high comorbidites with SUD
- 70-90% nicotine dependence
- Smokers with psychiatric conditions = 34% of all
cigarette use
- AUD = 10.1%; Schizophrenia = 9.0%; together = 16%
Chicken or Egg: shchizophrenia and nictoine
Does schizophrenia cause nicotine addiction,
or does nicotine addiction cause schizophrenia
See high rates of smoking before onset, also see onset after
Does high rates of smoking before onset cause hypofrontality that we see in schizophrenia? or does hypofrontality seen in schizophrenia cause individuals with schizo. to be more susceptible to drug use
Peptides
Peptides are two or more amino acids linked by peptide bonds
Many of these are: Endogenous Opioids Receptors