Week 3

Question 1

Tetrahydrofolate is the reduced form of vitamin ____ and plays an important role in _____

Answer 1

Folate (Folic Acid) (Vitamin B9)

-one carbon atom transfers

Question 2

Name the 3 important products that Tetrahydrofolate can be converted to for important biosynthetic processes

Answer 2

• N 10 formyl THF
• N5, N10- methylene THF
• N5 -methyl THF

Question 3

what does N10-formyl THF produce?

Answer 3

purines: A and G

Question 4

what does N5, N10 methylene THF produce?

Answer 4

Thymidine monophosphate synthesis, serine synthesis from glycine

Question 5

what does N5-methyl THF produce?

Answer 5

methionine from homocysteine

Question 6

what is the most common form of nutritional anemia?

Answer 6

Iron deficency microcytic anemia is the most common form of nutritional anemia.

Question 7

A deficiency in either ____ or ____ leads to macrocytic anemia

Answer 7

• folate

- Vitamin B12

Question 8

describe how a deficiency in folic acid leads to megaloblastic anemia?

Answer 8

folic acid deficiency results in
diminished synthesis of purines and TMP, which
leads to an inability of cells (including RBC
precursors) to make DNA and, therefore, an
inability of cells to divide.

Question 9

methotrexate inhibits ____ and can be used to treat _____

Answer 9

• dihydrofolate reductase

- neoplastic diseases

Question 10

what vitamin is given to women during pregnancy to prevent spina bifida or anencephaly?

Answer 10

Folate (Folic acid)