Week 207 - OSA and Chest Wall Flashcards
Week 207 - OSA and Chest Wall: Where does control of the respiratory rhythm come from?
Medulla Oblongata
- Ventral respiratory group (mostly expiratory firing)
- Dorsal respiratory group (mostly inspiratory firing)
Week 207 - OSA and Chest Wall: What is the group pacemaker hypothesis?
• Membrane properties of individual neurones and connections between neurones, generate rhythmic bursts of firing.
Week 207 - OSA and Chest Wall: What is the role o the pontine respiratory group?
Fine tunes the respiratory rhythm.
Week 207 - OSA and Chest Wall: What are the four airway and lung reflexes that fine tune respiration?
- Nose + upper airways; irritant receptors > Vagus nerve.
- Stretch receptors > Vagus nerve.
- Irritant receptors > Vagus nerve > Bronchoconstriction.
- J receptors in alveoli - Engorged capillaries / interstitial fluid > Vagus nerve > Dyspnoea.
Week 207 - OSA and Chest Wall: What is the main chemical stimulus for breathing when PaO2 and PaCO2 are normal?
Co2
Week 207 - OSA and Chest Wall: In what situation can O2 directly stimulate breathing?
At low levels of PO2.
Week 207 - OSA and Chest Wall: What is the name of scoring system for assessment of sleep apnoea?
Epworth sleepiness scale.
Week 207 - OSA and Chest Wall: What are the ABG results for a person in Type I respiratory failure?
PO2 : Low
PCO2 : Normal (or low)
pH : Normal (or alkalosis)
HCO3 : Normal (or low)
Week 207 - OSA and Chest Wall: What are the ABG results for a person in Type 2 respiratory failure?
PO2 : Low
PCO2 : High
pH : Acidosis (or normal)
HCO3 : High (or normal)
Week 207 - OSA and Chest Wall: What is the FEV1, FVC and FEV1:FVC in a restrictive lung disease?
- FEV1 and FVC are both reduced since there is a reduced volume.
- The ratio will therefore be normal (or may increase since FVC is reached quickly).
Week 207 - OSA and Chest Wall: What are the three types of Acid Maltase deficiency?
- It is an autosomal recessive disease.
- Defect of lysosomal enzyme.
- Causes painless, slow, progress proximal muscle myopathy. (Diaphragm involvement is common, presents with respiratory failure)
Week 207 - OSA and Chest Wall: What are the three types of Acid Maltase deficiency? Describe each briefly.
- Infantile - Organomegaly, skeletal muscle involvement, CVS, Resp. failure and usually death <2years.
- Juvenile - limited survival.
- Adult - Best prognosis.
Week 207 - OSA and Chest Wall: What is the definition of obstructive sleep apnoea?
Stopping (or slowing) of breathing during sleep due to obstruction of the upper airway.
Week 207 - OSA and Chest Wall: What is the incidence of OSA?
2-5% men and 1-2% of women have OSA worthy of treating.
Week 207 - OSA and Chest Wall: What is the aetiology of OSA?
- Pharyngeal incompetence brought on by sleep.
- Periods of arousal from sleep to clear airway.
- Markedly fragmented sleep.
- Daytime consequences (Sleepiness)