Week 2 Flashcards
Timing and sensitive periods for fatal development
*look up image
Effects of environment - poverty
Associated with: – Increased stress – Fewer but more hostile interactions – External environmental risks – Serious developmental risks
Teratogens
- harmful environmental agents/conditions that impair prenatal development and lead to death, birth defects, or later emotional, behavioural, and/or intellectual impairments
- Usually these abnormalities arise in the third to eighth weeks of pregnancy, when the major organ systems are forming
Examples of teratogens
- Prescription drugs: thalidomide, accutane (Vitamin A)
Illegal drugs: marijuana, cocaine alcohol and tobacco
(Pre-natal exposure to smoking alters gene expression, linked to ADHD) - Environmental hazards: X-rays, pollution, disease: Rubella, HIV/AIDS, STDs
- Parental factors: maternal malnutrition, stress, age; paternal age, Vitamin C deficiency, exposure to toxins, smoking
Teratogen risk factors
Dose Heredity Interaction effects Timing sensitive and critical periods Environmental interactions
Teratogen risk factor - dose
Generally larger dose over
longer time → more damage May be safe thresholds.
-> However, example: alcohol
- WHO recommends no known safe level of alcohol during pregnancy
- Australian NHMRC Guidelines- safest = no alcohol during pregnancy or breastfeeding
Teratogen risk factor - heredity
e.g., alcohol
dehydrogenase gene
Teratogen risk factor - interaction effects
e.g., alcohol + marijuana, no safe thresholds
Teratogen risk factor - timing sensitive and critical periods
*look up image
Teratogen risk factor - environmental interactions
e.g. low SES, smoking, & developmental delays (Perera et al., 2006)
Fetal alcohol spectrum disorders
Result from exposure to alcohol (again a teratogen)
• 1 – 3 per day: ARND (Alcohol-related Neurodevelopmental Disorder) or Fetal Alcohol Effects
• > 3 per day or binging (5+) in early pregnancy: Fetal Alcohol Syndrome
Expressions of FAS depend on
– Timing of alcohol consumption relative to the stage of fetal development
• Incl. exposure prior to pregnancy, incl. by father
• Most vulnerable between 3 – 6 weeks
– Dose and frequency of consumption
– Socio-behavioural risk factors (maternal age/duration of drinking, low SES, race, genetic differences, polydrug use)
Infant brain development
• At birth
– birth: 25% adult brain weight
• 2 years: 80%
– Increases due to dendrite growth and myelination
5 fold increase in dendritic density by 2 years (Diamond, 1990)
Determinants of brain development
Maturation + Stimulation • Deprivation studies e.g., Rozenweig’s (1984) rat experiments e.g. Human deprivation studies (Beckett et al., 2006) *look up image - Beckett 2006
Depth perception
Ability to judge distance of objects
• Tied to motor development, esp. crawling
–the Visual Cliff