Week 2 Flashcards
what is altered when you change nucleotides
the codon message leading to phenotypic changes
how can a nucleotide change alter heritable phenotype
if the nucleotides are changed in reproductive cells (somatic cells dont matter for heritability)
what kind of substitution happens when a codon is changed
replacement substitution
where was a replacement substitution first noted
in sickle cell anemia (val for glu)
what are two casual ways for nucleotide changes to occur
replication errors, damaged sites
what are some ways for a nucleotide to be damaged
chemical mutagens and radiation
what are the types of changes happening when a nucleotide changes a codon
transition or transversion
what nucleotides are changed in transition
purine for purine or pyrimidine for pyrimidine (AG or TC)
what nucleotides are changed in transversion
purine for pyrimidine (ACT or GCT)
what type of nucleotide change is more common
transition is more common than transversion
why is transversion less common than transition
transversion is easier to detect in proofreading ebcause it causes a conformational change to the DNA
which group has higher point mutation rates
sexually reproducing organisms have higher point mutation rates
the number of new alleles per individual should match the ____
mutation rate
what is the human mutation rate
1.6 per person (0.8 for sperm + 0.8 for egg)
machinery of DNA replication and repair are encoded by what
all are gene encoded proteins
what are the impacts of mutation to a species
mutations can be detrimental, but mutations are the source of individual variation
why can slight allelic variation help a population
can help population overcome change in environment so they can thrive
if you have a high mutation rate, what is your survival rate
low
how do new genes evolve
genes take on new functions and are evolved
how are new genes formed
gene duplication and unequal crossover
how does unequal crossover of genes work
loss of genes for one chromosome and gaining for the other chromosome (chromosomal alteration)
what is a chromosomal alteration
change in the morphology of chromosomes
what are some consequences of chromosomal alteration
affect gene order and organization, produces duplication and deletions, inversions, polyploidy
what is a chromosomal inversion
break occurs in the chromosome and it flips and reanneals (chromosome attachment can get mixed up)
what is the nickname for genes that have been inverted
supergenes
what is polyploidy
change in number of chromosomes per set
what is polyploidy most common in
plants not animals ( thought it can happen in animals)
what are some animal examples of polyploidy
salamanders, frogs
when is viability in polyploidy low
when polyploid is crossed with normal ploidy
what is a consequence of polyploidy
can cause reproductive isolation
how can you assess genetic diversity
direct measurement of allelic and genotype frequency
what is a direct method for measuring geneti diversity
gel electrophoresis
what does genetic diversity allow for
evolution allows a change in allelic frequency over time