Week 2 Flashcards
How can you identify areas of epithelila loss?
Fluorescein drops
What can traumatic uveitis present with?
Dilated pupil, sensitive to light
What is a hyphaema?
Blood (red blood cells) in the anterior chamber
What is a hypoium?
White blood cells in anterior chamber
What test can be done for a penetrating injury?
Siedels test
What condition results from penetrating injury to one eye, autoimmune reaction in BIOTH eyes, inflammation in BOTH eyes and may lead to bilateral blindness?
SympATHETIC OPHTHALMIA
What might a hammer and chisel injuries cause to eye?
Intra-ocular foreign bodies
What should you always do when suspecting an intra-ocular foreign body?
X-ray
What substance can give cicatrising changes to conjunctiva and cornea?
Alkali
What might limbal ischaemia present like?
China white sign
What must be done for chemical injuries to eyes?
Thorough irrigation
What substances should you be aware of in chemical injuries?
Lime and cement
What should be used for irrigation?
2l saline
What is the term for swollen spotic discs secondary to raised intracranial pressure?
Papilloedema
What should all patients with bilateral optic disc swelling be suspected of having?
Raised ICP due to space occupying lesion
What does interruption of axoplasmic flow and venous congestion cause?
Swollen discs
What three components make up intracranial pressure?
Brain - 80%
Blood - 10%
CSF - 10%
Whast should you always check with patients with raised intracranial pressure and disc swelling?
Blood pressure
Where is most CSF produced?
In lateral ventricles by choroid plexus
What exam is ophthalmoscopy a part of?
Cranial nerve 2 examination
What type of age related macular degeneration can cause sudden visual loss?
Wet type
What presents with sudden visual loss, painless, RAPD and pale oedematous retina with threat like retinal vessels?
Occlusion of retinal circulation - central retinal artery occlusion
How do you manage CRAO within 24 hours?
Ocular massage - try to convert CRAO to BRAO
cAROTID Doppler
Name two variants of retinal artery occlusion?
Branch retinal artery occlusion
Amaurosis fugax - transient CRAO
What presents with transient painless visual loss, like a curtain coming down and lasts 5 minutes with full recovery?
Transient CRAO - amaurosis fugax
How do you manage amaurosis fugax?
Immediate referral to TIA clinic
Aspitin
What presents with sudden visual loss, moderate to severe visual loss, retinal haemorrhages, dilated tortuous veins and disc swelling and macular swelling?
CRVO
Name a drug used to treat CRVO?
anti-VEGFs
What is the difference in colour between artery vs vein occlusion?
Artery goes pale
Vein goes dark
How does the optic nerve head circulation become occluded in ischaemic optic neuropathy?
Posterior ciliary arteries become occluded resulting in infarction of the optic nerve head
Name two types of ischaemic optic neuropathy that cause sudden, profound visual loss with swollen disc?
Arteritic - inflammation (GCA)
Non-arteritic
What signs are seen in ION?
Pale, swollen disc
What presents with loss of vision, floaters, loss of red reflex, haemorrhage on fundoscopy?
Vitreous haemorrhage
How is vitreous haemorrhage treated?
Vitrectomy
What presents with painless loss of vision, sudden onset of flashes/floaters, may have RAPD and the management is usually surgical?
Retinal detatchment
What involves new blood vessel growth under retina - leakiage causing build up of fluid/blood and eventually scarring?
Wet ARMD
What are the symptoms and signs of wet ARMD?
Rapid central visual loss
Distrortion
Haemorrhage/exudate
How is wet ARMD treated?
Anti-VEGF treatment - injected into vitreous cavity. stops new blood vessels growing by binding to VEGF
How might gradual visual loss present with early and late?
Early = redduced VA Late = decreased visual field
List the causes of gradual visual loss? cardigan
- Cataract
- Age related macular degeneration (dry)
- Refractive error
- Diabetic retinopathy
- Inherited diseases - retinitis pigmentosa
- Glaucoma
- Access to eye clinic - non-urgnet
What drugs can cause cataracts?
Steroids
What are the symptoms and signs of dry ARMD?
Gradual decline in vision and central vision missing (scotoma)
Drusen - build up of waste products below RPE
Atrophic patches of retina
What is myopia?
Short sighted
What is hypermetropia?
Long sighted
What is astigmatism?
Usually irregular corneal curvature
What is the term for progressive optic neuropathy?
Glaucoma
What do patients with closed angle glaucoma present with?
Painful, red eye/visual loss, headache, nausea and vomiting
Give some signs of open angle glaucoma?
Cupped disc
Visual field defect
May or may not have IOP
Is the epithelium liphobic or hydrophobic?
Hydrophobic
Is the stroma hydrophobic or hydrophilic?
Hydrophilic
What type of drugs penetrate the epithelium and what ones penetrate the stroma?
Lipid soluble drugs - epithelium
Water soluble drugs - stroma
Name a drug with both lipohpilic and hydrophilic properties?
Chloramphenicol
Name two substances which make steroids more hydrophobic?
Alcohol or acetate
Name a substance which makes steroids more hydrophilic?
Phosphate
Which one - pred acetate or pred phosphate has better penetration in uninflamted cornea?
Prednisolone acetate
Name a preservative which disrupts lipid layer of tear film and enhances corneal penetration?
Benzalkonium
What two eye side effects can steroids cause?
Cataract and glaucoma
Name the first line glaucoma medication?
Prostanoids - latanoprost
Name four other glaucoma medications other than prostanoids?
- Betablockers
- Carbonic anhydrase inhibitors
- Alpha adrenergic agonist
- Parasympathomimetic - pilocarpine
Give four uses for fluorescein?
- Shows corneal abrasion
- Tonometry
- Diagnosing nasolacrimal dut obstruction
- Angiographt
What drugs cause pupil dilation by blocking parasympathetic supply to iris?
Mydriatics - trpicamide
Side effects: blurring, AACG
What class of drugs cause pupils to dilate?
Sympathomimetics
Name a TB drug which causes optic neuropathy?
Ethambutol - colour vision
Name a drug which causes maculopathy?
Chloroquine
What is the main cause of neuro-opthalmic disease?
Vascular
What way does lateral rectus move the eye?
Abduction
Give four causes of 6th nerve palsy?
- Microvascular
- Raised intracranial pressure
- Tumour
- Congenital
Give three movements of superior oblique?
Intorsion
Depression in adduction
Abduction (weak)
What does a head tilt suggest?
4th nerve palsy
What can cause bilateral IV palsy?
Blunt head trauma
Give four causes of 4th nerve palsy?
- Congenital decompensated
- Microvascular
- Tumour
- Bilateral - closed head trauma
What does occular position of down and out suggest?
3rd nerve palsy
Give five causes of third nerve palsy?
- Microvascular
- Tumour
- Aneurysm
- MS
- Congenital
Whast would be the cause of a painful third nerve palsy?
Aneurysm
What causes progressive visual loss, pain behind eye especially on movement, colour desaturation, central scotoma and gradual recovery?
Optic neuritis
Pathology where - causes quadrantanopia?
Optic tracts and radiation
Pathology where - causes homonomous defect, macular sparing and congruous?
Occipital cortex