Week 2 Flashcards
What is the source of undifferentiated T lymphocytes?
Bone marrow
Surface markers on lymphocytes can be used to:
1) Identify and count CD4+ and CD8+ cells.
2) Classify leukemic cells.
3) Monitor patients on immunotherapy.
When mature T lymphocytes leave the thymus, their T-cell receptors are either CD4+ or:
CD8+.
In antigen recognition by T lymphocytes, each cell:
1) Is clonally restricted.
2) Expresses a receptor able to react with a given peptide.
3) Can only recognize a limited number of antigens.
Diminished immunoglobulin levels can be related to:
A deficit of activated T lymphocytes.
Functions of the complement system include
1) Host defense against infection, such as chemotaxis.
2) Clearance of apoptotic cells.
3) Clearance of immune complexes from the tissues.
The alternate complement pathway is activated by:
Bacterial exotoxins.
The physiologic or cellular consequences of complement activation can include:
1) Production of inflammatory mediators.
2) Cytolysis or hemolysis.
3) Opsonization.
The classical complement pathway is activated by:
Antigen-antibody complexes.
Increased susceptibility to pyogenic infections can be caused by:
1) Deficiency of the opsonic activities of complement.
2) Any deficiency that compromises the lytic activity of complement.
3) Deficient function of the mannose-binding lectin pathway.
The membrane attack complex (MAC) is characterized by:
MAC components are the same in the final common pathway of complement activation.
C5-8 complex polymerizes C9 to form a tubule known as MAC.
MAC allows for the influx of Na+ and H2O, which produces lysis.
The cell that produces IL-3, IL-4, IL-10, IL-13, IFN-a, IFN-y, and TNF-b is:
T helper 2 cells.
The earliest host response to vaccination is a(n):
Innate immune response.
Immune responses to parasitic infection include:
Immunoglobulin production.
Antibody-dependent, cell-mediated cytotoxicity.
Cell defenses, such as eosinophils and T lymphocytes.
