Week 17: (B) Immunoglobulins Flashcards
what is the link between antigens and a small number of effector cells?
Antibodies = adapter molecules
What is unique in each VL and VH domain?
3 hypervariable loops or CDRs
different in each antibody
What are the hyper variable regions?
they are 3 loops in the heavy VH and VL domains that express unique amino acid sequences. unique in every antibody.
responsible for binding to antigen
What region in the VL and VH are responsible for antigen binding?
CDR=complementary determining region
also known as the hyper variable loops
What creates the antigen binding site?
when the 6 CDRs from Vl & VH combine/pair
Why is the Antigen binding site unique?
the 6CDRs are unique amino acids for every antibody
bind to a unique & specific antigen
What would you call the uniqueness of the CDRs to an antigen?
complementary
What allotrope of Carbon is used as an antibody?
anti-buckminsterfullerene
What type of interaction is the binding of antibody to antigen?
non-covalent
What are the specific types of non covalent forces that occur when antibody binds to antigen?
electrostatic forces, hydrogen bonds, van Der Waals forces, hydrophobic forces
What is the most abundant immunoglobulin?
IgG (10mg/ml)
What are the masses of IgG HC and LC?
HC= 50kDa LC= 25kDa
What are the 4 subclasses of IgG?
1, 2, 3, 4
How efficient is IGg at triggering complement and phagocytosis via Fc R?
VERY EFFICIENT
What class of immunoglobulin is passed from mother to foetus?
IgG
protects baby in first few months of life
