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Biomolecular Mechanisms > Week 13: TCA Cycle > Flashcards

Week 13: TCA Cycle Flashcards

1
Q

Where does the TCA cycle occur?

A

Mitochondrial matrix

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2
Q

How many reactions in total?

A

8

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3
Q

What mnemonic helps with the TCA cycle?

A

A Clown In Kilimanjaro Sings Songs For Money Only

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4
Q

What are the 6C moleules?

A

Citrate, isocitrate

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5
Q

What are the 5C molecules?

A

alpha-ketoglutarate

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6
Q

What are the 4C molecules?

A

succinyl-Co-A, succinate, fumarate, malate & oxaloacetate

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7
Q

What is the 2C molecule?

A

Acetyl-Co-A

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8
Q

What reaction occurs between citrate and isocitrate?

A

enzyme: aconitase

dehydrogenation

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9
Q

What is the reaction between isocitrate and alpha-ketoglutarate?

A

enzyme: isocitrate dehydrogenase
NAD+–>NADH
CO2 decarboxylated

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10
Q

What is the reaction between alpha-ketoglutarate and succinyl-Co-A?

A

enzyme: alpha-ketoglutarate dehydrogenase
NAD+–>NADH
CO2 decarboxylated

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11
Q

What is the reaction between sucinyl-Co-A and succinate?

A

enzyme: succinyl thiokinase

GDP+Pi–> GTP

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12
Q

What is the reaction between succinate and fumarate?

A

enzyme: succinate dehydrogenase

FAD+–>FADH2

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13
Q

What is the reaction between fumarate and malate?

A

enzyme: fumarase

H20 goes off

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14
Q

What is the reaction between malate and oxaloacetate?

A

enzyme: malate dehydrogenase

NAD+–>NADH

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15
Q

What is the reaction between oxaloacetate and Acetyl-Co-A?

A

enzyme: citrate synthase

CoA off

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16
Q

What enzyme does not appear in the mitochondrial matrix?

A

succinate dehydrogenase

17
Q

what are substrates that can enter the TCA cycle?

A

carbohydrates, lipids, proteins

18
Q

TCA negative modulator?

A

High ATP, NADH & ACoA= plenty energy (don’t need any more)

19
Q

TCA positive modulator?

A

High ADP & NAD+ = lack of energy ( need more so enter cycle)

20
Q

What can inhibit TCA cycle?

A

High succinyl-Co-A –> plenty of precursor molecules for biosynthetic reactions.
A lot of carbon in molecules inhibit cycle

21
Q

How does the TCA cycle inhibit glycolysis?

A

citrate inhibits phosphofructokinase enzyme

Shut down anymore input into cycle

22
Q

What happens to Acetyl-Co-A when it does not need to enter the TCA cycle?

A

diverted away to the fatty acid cycle

eaten too much and stored as fat

23
Q

What are the products of the TCA cycle?

A

1 GTP
3 NAD+ 3H+
1 FADH2
2 CO2

Biomolecular Mechanisms (34 decks)

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