Week 12 Cell Death

Question 1

What is Homeostasis in regard to Cell Death

Answer 1

The balance between proliferation and cell death

Cells die when they have served their function, are diseased, are damaged or have turned senescent

Question 2

Passive Cell Death

Answer 2

Necrosis
- accidental, inflammation, irreversible, detrimental and fatal

Question 3

Active Cell Death

Answer 3

Apoptosis
- Programmed
- Cell contributes to death
- removes, infected, damaged, old, mutates or unwanted cells
- not harmful to others
-no inflammation

Question 4

Apoptosis functions

Answer 4

Sculpting structures
Deleting structures
Regulating cell number
elimination

Question 5

Autophagy

Answer 5

Self-digestion mechanism (Marie Condo)
- removes damaged organelles, malformed proteins and non-functional proteins

Question 6

Types of Autophagy

Answer 6

Macroautophagy
Microautophagy
Chaperone-mediated Autophagy

Question 7

Macro Autophagy

Answer 7

Formation of Double membrane-bound structures the fuse with Lysosomes

Question 8

Micro Autophagy

Answer 8

Lysosomes directly engulf portions of the cytoplasm

Question 9

Chaperone-mediated Autophagy

Answer 9

Proteins that carry motif (KFERQ) bind to chaperone which is then transported to lysosomes