Week 1: Tuesday Flashcards
what does the autonomic nervous system do
- innervates viscera - unconscious control
- mediates homeostasis
- visceral sensory and visceral motor neurons that function in visceral reflexes
- takes 2 motor neurons in series to innervate organs
- parasympathetic and sympathetic
- dual innervation of organs
what is homeostasis
maintenace of critical physiological parameters of the internal environment within the limits comparible with life
what are the functions of the parasympathetic divistion
- conserves and restores energy reserves (anabolic)
- promotes digestion, absorption, and storage
- protective - miosis - contriction of pupil
- rest and digest
where does the parasympathetic nervous system originate
- from a restricted part of brain and spinal cord (cranial-sacral)
- has own set of peripheral ganglia
what are the functions of the sympathetic division
- prepares body for action
- mobilizes energy stores (catabolic)
- mediates responses to stress
- fight or flight
where does the sympathetic nervous system originate
- from restricted part of spinal cord (thoracolumbar)
- has own set of peripheral ganglia
what is dual innervation
- many organs have a sympathetic and a parasympathetic innervation (one excites and other inhibits)
- some organs don’t (skin, sweat glands, arrector pili muscle, vascular smooth muscle, adrenal gland and adipose tissue) - only sympathetic
resting membrane potential
- net negative charge inside the cell membrane
- ion pumps maintain concentration gradient
what are contractile cardiac cells
- generate force
- not autorhythmic, but do conduct action potentials
what are autorhythmic cardiac cells
- provide a pathway for spreading excitation through the heart (pacemaker cells, conduction fibers)
- don’t generate much contractile force
what are fast-response action potentials
- contractile cardiac cells
- Na+ driven (fast Na+ channels)
what are slow-response action potentials
- autorhythmic cardiac cells
- Ca2+ driven (L-type Ca2+ channels)
- pacemaker potentials lead to spontanous action potentials
- due to hyperpolarization-activated cyclic nuceotide-gated (HCN) channels (funny current) and T-type calcium channels
what are the 3 steps in action potentials in contractile cardiac cells
- rapid depolarization
- plateau
- repolarization
what are the 6 important membrane currents in contractile cardiac cells
- INa: sodium current
- ICa: L-type Ca current
- Ito: transient outward K current
- IKr: rapidly activated delayed rectifying K current
- IKs: slowly activating delayed rectifying K current
- IK1: inward rectifying K current
what membrane currents are in phase 4 of autorhythmic cells
- If: funny current, HCN channel
- ICa2+ (T): T-type voltage gated channel
what membrane currents are in phase 0 of autorhythmic cells
ICa2+ (L): L-type voltage gated channel
what phases are absent in autorhythmic cells
phase 1 and 2
what membrane currents are in phase 3 of autorhythic cells
IK: potassium current, dlayed rectifier potassium
what membrane current is important for parasympathetic regulation of HR
IKACh: rectifying potassium current
what happens at intercalated disks
- desmosomes provide structural strength
- cells linked by gap junctions