Week 1 Readings Flashcards
Hormone produced by adipocytes
Increase insulin sensitivity
Decrease release of glucose from liver
Protect blood vessels from inflammatory damage
Adiponectin
Metabolic disorder
High glucose levels
Altered metabolism of protein and fats
Thickening of basement membrane
Diabetes mellitus
DPP-4
Enzyme that quickly metabolzes glucagonlike polypeptide-1
Receptors found in adipose, muscle, liver, satiety center, GI tract
Part of a signaling system with in body to keep in a state of Energy Gain
Endocannabinoid Receptor
Produced in the GI tract in response to carbohydrates
Increases Insulin
Decreases Glucagon
Slows GI emptying
Stimulates Satiety in brain
Glucagonlike Polypeptide-1
Storage form of glucose
Broken down for rapid increase of glucose level
Glyogen
Glycoslated hemoglobin
Blood Glucose marker
Provides a 3 month average of blood glucose levels
Incretins
Peptides produced in the GI tract in response to food
Moderate Insulin & Glucagon
Endocrine part of the pancreas releases hormones in a collection of tissue called the Islets of Langerhan.
The islets contain
Alpha cells (their function)
Beta cells (their function)
Delta
Alpha: Glucagon Increase BS
Beta: Insulin Lower BS
Delta: Somastatin Inhibits Glucagon & insulin in times of low BS
GLP-1 is an incretin that does what _______
In preparation for nutrients that will soon be absorbed
Lowers Glucagon
Raises Insulin
Why do obese people get Diabetes
Not enough insulin receptor sites (due to body being larger)
Thus, cannot produce enough insulin to lower BS
Glucagon can increase BS 2 ways
- Break down of glycogen store in liver
- Stimulate liver to convert protein into glucose (gluconeogensis)
Insulin can affect this electrolyte
Making it lower
K potassium
Which drug interactions blocks the symptoms of hypoglycemia
Beta-blockers
Most common adverse effect of Sulfonylureas is…
Hypoglycemia
