Week 1 Objectives 7: relate Sertoli cells to spermatogenesis and the blood testis barrier Flashcards

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1
Q

Sertoli cells “other” name

A

sustentacular cells

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2
Q

Sertoli functions

A

Support and maintenance
Secretes estrogen, inhibin, anti-Mullerin factor
Phagocytize residual bodies from spermatozoa
Forms blood-testis barrier
mantains and coordinates spermatogenesis

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3
Q

Blood testis barrier

A

Sertoli form immunological barrier between developing sperm cells and body, and spermatogonia

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4
Q

how does the blood testis barrier work

A

Surface adhesion complexes bind apical surfaces of Sertoli cells to late spermatids

Complexes deteriorate, releasing spermatids into lumen

Laminin from disintegrated adhesion complexes + cytokines + proteinases = break down tight-junctional proteins of the blood-testis barrier, permits developing spermatocytes to move closer to lumen

Testosterone stimulates formation of new blood testis barrier closer to basal lamina

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