Lecture 8: Signaling Pathways, objective 2, diagram major signaling pathways involved in morphogenesis

Question 1

Delta Notch Pathway: components and actions (8)

Answer 1

1. Delta molecule (signaling molecule) signals Notch receptor
2. Proteolytic cleavage of Notch’s intracellular receptor (NIM)
3. NIM combines with Deltex
4. NIM-Deltex translocate into the nucleus
5. NIM-Deltex complex with Suppressor of hairless
6. NIM-Deltex-Suppressor bind to Enhancer of split
7. NIM-Deltex-Suppressory-Enhancer represses gene expression

Question 2

Receptor Tyrosine Kinase Pathway

Components and Actions

Answer 2

components
FGF binds to receptor tyrosine kinase

G protein is activated witch leads to

1. activation of pathway components: RAS, RAF, MAP Kinase, and ERK