Lecture 8: Signaling Pathways, objective 2, diagram major signaling pathways involved in morphogenesis Flashcards

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1
Q

Delta Notch Pathway: components and actions (8)

A
  1. Delta molecule (signaling molecule) signals Notch receptor
  2. Proteolytic cleavage of Notch’s intracellular receptor (NIM)
  3. NIM combines with Deltex
  4. NIM-Deltex translocate into the nucleus
  5. NIM-Deltex complex with Suppressor of hairless
  6. NIM-Deltex-Suppressor bind to Enhancer of split
  7. NIM-Deltex-Suppressory-Enhancer represses gene expression
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2
Q

Receptor Tyrosine Kinase Pathway

Components and Actions

A

components
FGF binds to receptor tyrosine kinase

G protein is activated witch leads to

  1. activation of pathway components: RAS, RAF, MAP Kinase, and ERK
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