Lecture 10: Objective 2 Flashcards

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1
Q

Wnt3: origin, target, effect. type

A

O: posterior epiblast
T: epiblast
E: induces expression of nodal

O: primitive streak
T: self?
E: induces expression of nodal

signaling molecule

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2
Q

Lefty 1 and Cer 1: origin, target, effect

A

O: anterior hypoblast
T: nodal
E: blocks expression of nodal in anterior epiblast, confines expression to the posterior epiblast

signaling molecule

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3
Q

Nodal: origin, target, effect. type

A

O: epiblast
T: multiple
E: establishes a posterior signaling center which induces formation of the primitive streak

signaling molecule

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4
Q

Cerebrus-like: origin, target, effect. type

A

O: anterior visceral endoderm
T: self
E: inhibits development of posterior structures

signaling molecule

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5
Q

Otx-2 and Lim-1: origin, target, effect. type

A

O: anterior visceral endoderm
T: self
E: associated with induction of anterior CNS

transcription factors

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6
Q

DKK-1: origin, target, effect. type

A

O: anterior visceral endoderm
T: blocks Wnt
E: inhibits development of posterior structures

signaling molecule

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7
Q

Noggin: origin, target, effect. type

A

O: primitive node
T: ectoderm
E: neural inducer

signaling molecule

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8
Q

Chordin: origin, target, effect. type

A

O: primitive node
T: ectoderm
E: neural inducer

signaling molecule

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9
Q

Nodal: origin, target, effect. type

A

O: primitive node
T: ectoderm
E: induces primitive streak and helps to establish left-right symmetry

O: primitive streak
T: self?
E: induces primitive streak and helps to establish left/right symmetry

signaling molecule

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10
Q

Goosecoid: origin, target, effect. type

A

O: primitive node
T: chordin and noggin (genes)
E: activates genes

transcription factor

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11
Q

Foxa-2: origin, target, effect. type

A

O: primitive node
T: multiple
E: establishment of primitive node; initiates notochord function; establishes midline structures cranial to node

transcription factor

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12
Q

Brachyury: origin, target, effect. type

A

O: primitive node
T: primitive streak
E: notochord formation; normal movements of cells through primitive streak

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13
Q

Shh: origin, target, effect. type

A

O: Prechordal plate
T: multiple
E: induces axial structures

signaling molecule

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14
Q

Cerebrus related 1: origin, target, effect. type

A

prechordal plate

normal head formation

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15
Q

goosecoid (again): origin, target, effect. type

A

O: prechordal plate
T: chordin, noggin (genes) in notochord
E: activates genes

transcription factor

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16
Q

Foxa-2 (again)

A

prechordal plate

chordin, noggin (genes) in notochord, activates genes

17
Q

Foxa-2 (again, again)

A

notochord
chordin, noggin (genes)
activates genes

18
Q

Shh (again)

A

primitive node
mulitiple targets
induces axial structures

signaling molecules

19
Q

Foxa-2 (again, again, again)

A

primitive node
chordin, noggin in notochord
activates genes

20
Q

Retinoic acid: origin, target, effect. type

A

O: primitive streak
T: Cdx
E: Hox (gene)

signaling molecule

21
Q

Wnt: origin, target, effect. type

A

O: primitive streak
T: Cdx
E: Hox (gene)

signaling molecule

22
Q

FGF: origin, target, effect. type

A

O: primitive streak
T: Cdx
E: Hox (gene)

signaling molecule

23
Q

Goosechoid (cough cough)

A

primitive node
chordin, noggin (genes)
activates genes