Week 1 Lec: Intro to Hema Flashcards
Define Hematology.
- Study of the disorder and abnormalities related or associated with the quality and quantity of the cellular elements of the blood
- Study of the laboratory procedure and techniques being used to examine the quality and quantity of the cellular elements of the blood
1657
describe worms in the blood by Athanasius Kircher
1658
discovery of erythrocytes by Swammerdam
1674
human erythrocytes described by Van Leuwenhoek
1842
platelets were described
1846
PMN distinguished from other leukocytes by Wharton Jones
1879
first complete classification of leukocytes by Ehrlich
1902
development of Wrights stain by James Homer Wright
1920
hematology was considered a separate science from clinical pathology
A
without
blast
youngest/nucleated
-chromic
color
-cyte
cell
Dys
abnormal
-emia
in the blood
Ferro
iron
Hyper
increased
Hypo
decreased
Iso
equal
Macro
large
Mega
very large/huge
Micro
small
Myelo
marrow
Normo
normal
-oid
like
FBC
Full Blood Count
Fl
Femtoliter
Hb
Hemoglobin Concentration
Hct
Hematocrit
MCH
Mean Cell Hemoglobin
MCV
Mean Cell Volume
MCHC
Mean Cell Hemoglobin Concentration
CBC
Complete Blood Count
PG
Picogram
A life sustaining fluid which circulates through the heart and blood vessels.
Blood
It carries oxygen and nutrients to the ________ and waste products to the _______,_______, and _______ where they can be removed from the body
tissues; lungs, liver and kidney
What are the formed elements of blood?
erythrocytes, leukocytes, platelets, plasma
It is the liquid portion of unclotted blood.
Plasma
It is the fluid that remains after coagulation has occurred and clot has formed.
Serum
What are the components of plasma?
90% water, proteins, hormones, enzymes, lipids, and salts
Plasma appears?
hazy and pale yellow
Serum appears?
clear and straw-colored
Which has fibrinogen?
Plasma
What is the percentage of plasma in total blood?
55%
What is the percentage of erythrocytes in total blood?
45%
What is the percentage of buffy coat in total blood?
<1%
What is in the buffy coat of blood?
leukocytes and platelets
In vivo, blood is?
fluid/liquid
In vitro, blood?
coagulates in 5-10 minutes
Blood is ________ times thicker than water.
3.5-4.5
Blood makes up _____% of the total body component, or _____ml/kg.
6-8%, 60-80 ml/kg
Amount of blood in gms solid/mL?
20 gms solid/100 mL
TBV in adult male, female, and newborn, respectively?
5-6 L, 4-5 L, 250-350 mL
It can be described as the thickness and stickness of blood.
Blood viscosity
It is a measure of the resistance of blood to flow
Viscosity
The viscosity of blood is __ times more than that of water.
5
The viscosity and specific gravity of blood depends on?
RBCs and plasma proteins
It is a measure of the acidity or basicity of an aqueous solution. It is the negative decimal logarithm of hydrogen concentration.
pH
What is the normal pH range of blood?
7.35-7.45
What is the average pH of blood?
7.40
What is the pH of venous blood?
7.35
What is the pH of arterial blood?
7.45
How is pH of blood maintained?
excretion of CO2 by the lungs and excretion of H+ or OH by the kidney by the action of a buffer system (carbonate, phosphate, protein, hemoglobin)
It is the ratio of the density of a substance to the density of a reference substance.
Blood Specific Gravity
Specific gravity is also called?
relative density
Number of solutes dissolved in whole blood?
1.045 – 1.066
Number of solutes dissolved in serum?
1.024 – 1.028
Number of solutes dissolved in plasma?
1.025-1.029
Color of arterial blood?
bright red
Color of venous blood?
dark purplish red
In pulmonary arteries and veins, Hb with O2 is color?
purple
In pulmonary arteries and veins, Hb without O2 is color?
blue
What is the concentration of solutes dissolved in the blood called?
Osmolality
What is used to measure osmolality?
Osmometer
Reference range for osmolality is _______ mOsm/kg.
281-297 milliosmoles per kilogram
Give the 7 functions of blood.
- RESPIRATORY
- NUTRITIONAL
- EXCRETORY
- BUFFERING ACTION
- MAINTENANCE OF CONSTANT BODY TEMPERATURE
- TRANSPORTATION OF HORMONES AND OTHER ENDOCRINE SECRETION THAT REGULATES CELL FUNCTION
- BODY DEFENSE MECHANISM