Week 1 - Inflammation Flashcards
What are the main signs of inflammation?
Calor (Heat), Dolor (pain), Rubor (redness), Tumor (swelling), Functio Laesa (temporary loss of function due to above)
Explain heat during inflammation
Heat occurs when cytokines (prostaglandins) vasodilate and bring blood to the area.
Explain pain during inflammation
Pain occurs when specific cytokines (prostaglandins) are released in the complement system which sensitise nerve endings sending pain signals to the thalamus where it’s processed and send to somatosensory cortex which is responsible for the physical sensation of pain and helps localize and characterize the pain.
Explain redness in inflammation
Redness occurs at the site due to vasodilation and increased blood flow to the area.
Explain swelling during inflammation
Swelling occurs due to an increase in vascular permeability, allowing fluids, white blood cells and other inflammatory mediators to escape the bloodstream into the surrounding tissue.
Explain temporary loss of function during inflammation
This sometimes occurs due to the other 4 symptoms (pain, swelling, redness, heat).
What often initiates the inflammatory response?
The inflammatory response generally begins with harmful stimuli like pathogens including bacteria, viruses, which lead to infection.
Toxins and Trauma (ankle sprain)
Exercise-induced (muscle soreness after intense workout as a form of inflammation
What are the external factors that can trigger inflammation?
External factors include non-microbial elements like allergens, irritants, and toxic compounds, as well as microbial elements such as virulence factors and PAMPs (pathogen-associated molecular patterns).
What are PAMPs and their role in inflammation?
PAMPs (pathogen-associated molecular patterns) are microbial factors recognized by the immune system, triggering inflammation.
What are internal factors that can initiate inflammation?
Internal factors include DAMPs (damage-associated molecular patterns) that are released from cell damage.
What is a virulence factor?
Virulence factors are apart of the external microbial factors which help pathogens colonise tissues and cause infection
A virulence factor is a pathogens ability to infect someone
How do leukocytes (WBC) contribute to the inflammatory response?
Leukocytes, including granulocytes and agranulocytes, play key roles in PAMPs and DAMPS.
Pattern Recognition Receptors (PRRs)
Receptors on leukocytes that detect PAMPs & DAMPs and spark inflammatory response. They are non specific, have no memory and are quick to respond: minutes - hours
Types of Leukocytes
Granulocytes: Including neutrophils, eosinophils, basophils, and mast cells.
Agranulocytes: Including lymphocytes and monocytes (macrophages/dendritic cells).
Leukocytes initial responders
Macrophages, mast cells and dendritic cells