Week 1 Assigned Reading Flashcards

1
Q

According to the article, how much energy does the brain typically use?

A) 5% of the body’s energy at rest
B) 10% of the body’s energy at rest
C) 20% of the body’s energy at rest
D) 50% of the body’s energy at rest

A

C) 20% of the body’s energy at rest

“Although it accounts for around 2 per cent of our body weight, it uses some 20 per cent of the energy we burn at rest.”

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2
Q

What molecule signals mental fatigue after prolonged focus?

A) Glucose
B) Melatonin
C) Cortisol
D) Adenosine

A

D) Adenosine

“One molecule associated with mental fatigue is adenosine, which is a breakdown product of adenosine triphosphate (ATP), the key compound involved in metabolism. ‘When your brain is burning through ATP, it’s producing adenosine and literally signalling to itself: ‘Hey, I’m tired now,’ ‘ says McNay.”

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3
Q

Brain scanning studies on sex differences have found:

A) Large, consistent differences between male and female brains
B) No differences between male and female brains
C) Small differences in size of certain brain structures, even when controlling for total brain size
D) Differences only in language processing areas

A

C) Small differences in size of certain brain structures, even when controlling for total brain size

“It did reveal sex differences in the size of certain brain structures, even when controlling for total brain size: about a third of regions were larger in men and about a third were larger in women. But these differences were small – generally just a few per cent.”

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4
Q

What did a recent study find in post-mortem brains related to microbes?

A) A wide variety of microbes in different brain regions
B) Only viruses were found
C) No microbes were present
D) Microbes only in the cerebellum

A

A) A wide variety of microbes in different brain regions

“They found a wide variety of microbes, with different types and amounts in different brain regions. Lathe estimates that this brain microbiome contains some 100,000 species, comprising a subset of around one-fifth the gut microbiome.”

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5
Q

How many cell types were identified in the human brain, according to the 2023 human brain cell atlas?

A) About 1000
B) About 3300
C) About 5500
D) About 10,000

A

B) About 3300

“In October 2023, the first draft of an entire human brain cell atlas was published, comprising more than 3300 types of cell.”

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6
Q

When does cognitive performance tend to peak during the day for most people?

A) Early morning
B) Around noon
C) Late evening
D) Midnight

A

B) Around noon

“As a result, your performance tends to follow a predictable path: it is highest in the morning, peaking at around noon, then it starts dipping and, aside from a slight peak in the afternoon, it is downhill all the way to bedtime.”

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7
Q

What concept from physics has been applied to study consciousness?

A) Relativity
B) Quantum entanglement
C) Thermodynamics
D) Entropy

A

D) Entropy

“In 2014, Robin Carhart-Harris at the University of California, San Francisco, and his colleagues hypothesised that entropy may be a particularly useful one. Entropy describes how disordered a system is.”

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8
Q

How did adolescents perform compared to adults in a task involving uncertain rewards?

A) Much worse
B) Slightly worse
C) Exactly the same
D) Better

A

D) Better

“Far from making poor decisions, adolescents aced the test, uncovering more coins than older or younger participants. Teens show a similar aptitude in simulations of foraging tasks, where participants choose between exploiting one plot of land or exploring potentially greener pastures.”

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9
Q

What networks in the brain are involved in creative thinking, according to the “dual process theory”?

A) Default, executive, and salience networks
B) Limbic system and basal ganglia
C) Only the motor and sensory networks
D) Only the language processing areas

A

A) Default, executive, and salience networks

“Far from making poor decisions, adolescents aced the test, uncovering more coins than older or younger participants. Teens show a similar aptitude in simulations of foraging tasks, where participants choose between exploiting one plot of land or exploring potentially greener pastures.”

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10
Q

According to the article, why might forgetting be beneficial?

A) It helps with generalizing concepts
B) It allows more sleep time
C) It improves short-term memory
D) It increases brain size

A

A) It helps with generalizing concepts

“Far from making poor decisions, adolescents aced the test, uncovering more coins than older or younger participants. Teens show a similar aptitude in simulations of foraging tasks, where participants choose between exploiting one plot of land or exploring potentially greener pastures.”

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11
Q

According to the article, how does the brain allocate energy during mentally challenging tasks?

A) It uses less energy overall
B) It uses more energy overall
C) It increases energy use in task-relevant areas while decreasing it in others
D) Energy use remains constant throughout the brain

A

C) It increases energy use in task-relevant areas while decreasing it in others

“When the demand of a mentally challenging task increases, you see increased metabolism in the neurons that are responsible for the task,” says Lavie. At the same time, you see corresponding decreases in other brain areas.

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12
Q

What did brain scanning studies reveal about sex differences in the brain?

A) No differences between male and female brains
B) Small differences in size of certain brain structures, even when controlling for total brain size
C) Large, consistent differences between male and female brains
D) Differences only in hormone-producing regions

A

B) Small differences in size of certain brain structures, even when controlling for total brain size

“It did reveal sex differences in the size of certain brain structures, even when controlling for total brain size: about a third of regions were larger in men and about a third were larger in women. But these differences were small – generally just a few per cent.”

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13
Q

According to the article, what role does adenosine play in mental fatigue?

A) It increases energy production
B) It enhances memory formation
C) It improves focus
D) It signals tiredness to the brain

A

D) It signals tiredness to the brain

“When your brain is burning through ATP, it’s producing adenosine and literally signalling to itself: ‘Hey, I’m tired now,’ says McNay.”

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14
Q

How might neuroplasticity explain potential differences between male and female brains?

A) It suggests all differences are innate
B) It indicates differences are solely due to hormones
C) It suggests differences could be a result of different life experiences
D) It proves there are no differences between male and female brains

A

C) It suggests differences could be a result of different life experiences

“So, even if men tend to have a slightly larger part of the brain responsible for, say, spatial skills, that could be because they are more likely to take jobs that involve those activities. In other words, any brain differences between sexes could be a consequence of different gender roles, not their cause.”

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15
Q

What did the research on the brain’s microbiome suggest about Alzheimer’s disease?

A) Microbes have no impact on Alzheimer’s
B) Certain microbes were over-represented in brains with Alzheimer’s
C) Alzheimer’s completely eliminates the brain’s microbiome
D) Only viruses are associated with Alzheimer’s

A

B) Certain microbes were over-represented in brains with Alzheimer’s

“The researchers also found that, in people with Alzheimer’s disease, certain microbes were over-represented. These included species of Cryptococcus and Candida fungi, Streptococcus and Bacillus bacteria, as well as a currently unidentified alga.”

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16
Q

What did Andrea Volterra’s team discover about brain cells that challenges our understanding of neurons and glia?

A) They found a hybrid cell with features of both neurons and glia
B) Neurons can transform into glia
C) Glia can produce neurotransmitters
D) All brain cells are actually the same type

A

A) They found a hybrid cell with features of both neurons and glia

“Andrea Volterra at the University of Lausanne, Switzerland, and his colleagues described a new type of human brain cell that appears to act as a hybrid between neurons and glia.”

17
Q

How does the article suggest the adolescent brain differs from the adult brain in terms of learning and exploration?

A) Adolescent brains are less capable of learning
B) Adolescent brains are more disposed to explore new options
C) Adolescent brains are identical to adult brains
D) Adolescent brains are less responsive to rewards

A

B) Adolescent brains are more disposed to explore new options

“We tend to see these instances where adolescents outperform adults under conditions that are more uncertain or volatile,” says Wilbrecht. In such circumstances, adolescents seem more disposed to try new options, which may provide them with information about how to perform well in the future.”

18
Q

How does forgetting benefit the brain, according to the article?

A) It helps with generalising concepts
B) It improves memory retention
C) It creates more storage space
D) It increases neuron production

A

A) It helps with generalising concepts

“Far from being a problem, natural forgetting underpins one of our most unique and powerful traits – our ability to generalise.”

19
Q

What did the article say about the complexity of the human brain compared to other objects in the universe?

A) It is definitively the most complex object
B) It is less complex than galaxies
C) Its complexity is debatable and depends on the measure used
D) Its complexity cannot be measured

A

C) Its complexity is debatable and depends on the measure used

“Wolpert is in no doubt. It is pure hubris to see it as the most complex object in the universe, he says. ‘Nothing concerning humans is ever privileged. At best, it’s run of the mill – the brain included.’”

20
Q

According to the article, how does sleep affect brain function?

A) It only provides rest
B) It impairs memory formation
C) It’s when the brain lays down new long-term memories
D) It has no effect on brain function

A

C) It’s when the brain lays down new long-term memories

“But if it is memory you are trying to optimise, then deep sleep is when your brain does its heavy lifting – laying down new long-term memories from your day’s experiences.”

21
Q

What did the article say about creativity and brain networks?

A) Creativity only involves the default network
B) Creativity involves distinct networks for idea generation and evaluation
C) Creativity is solely dependent on the executive network
D) Brain networks are not involved in creativity

A

B) Creativity involves distinct networks for idea generation and evaluation

“Brain scans of people engaging in creative problem-solving suggest that idea generation and evaluation rely on distinct neural networks.”

22
Q

How did the article describe the energy use of the brain during different mental activities?

A) It uses more energy for complex tasks
B) It uses less energy for complex tasks
C) Energy use is constant regardless of the task
D) Energy use shifts between brain regions depending on the task

A

D) Energy use shifts between brain regions depending on the task

“Your brain allocates resources to its different parts depending on the mental activity being carried out. But there is a trade-off.”

23
Q

Summarise the brain’s energy usage, according to the article.

A

Uses 20% of body’s energy despite being only 2% of body weight

Energy use is constant regardless of mental activity

Local increases in energy use for specific tasks are offset by decreases elsewhere

Only about 1 calorie used for a self-control task

Adenosine builds up with mental effort, signalling tiredness as a “brake”

24
Q

What molecular “brake” is there on energy use and why is this important?

A

Adenosine builds up with mental effort, signalling tiredness as a “brake”

25
Q

The brain 20% of body’s energy despite being only 2% of body weight. Energy use is constant regardless of mental activity.

_________ builds up with mental effort, signalling tiredness as a “brake”

A

Adenosine

26
Q

Are male and female brains different?

A

Early studies showing size differences were flawed

Recent large studies show small differences (~few %) in some brain region sizes

Differences may be due to neuroplasticity from different experiences/roles

No clear functional differences have been established

More research needed to understand significance of subtle structural differences

27
Q

Does infection cause dementia?

A

Some cases of cognitive decline reversed by treating infections (e.g. fungal)

Brain has its own microbiome of ~100,000 species

Certain microbes over-represented in Alzheimer’s brains

Unclear if microbes cause degeneration or are a consequence

28
Q

What are the purported mechanisms of dementia caused by infection?

A

Direct toxicity, immune response and amyloid production

29
Q

How many known cell types are there in the mouse brain, according to the Allen Brain institute?

A

5200 cell types identified

30
Q

How many known cell types are there in the human brain, according to the Allen Brain institute?

A

Over 3300 cell types in draft atlas

31
Q

What does the article say about rosehip neurons?

A

Inhibitory, unique to humans, function unclear

32
Q

What does the article say about oligodendrocytes?

A

Produce myelin to insulate neurons

33
Q

What does the article say about microglia?

A

They are the brain’s immune cells

34
Q

What does the article say about microglia?

A

They are the brain’s immune cells

35
Q

What did Andrea Volterra’s team discover in 2023?

A

New hybrid neuron-glia cell type involved in spatial memory

36
Q

What did Andrea Volterra’s team discover in 2023?

A

New hybrid neuron-glia cell type involved in spatial memory

37
Q

Explain changes in cognition that might occur over the course of a day awake and then a night’s sleep, taking an individual’s chronotype into account where possible.

A

Daily: Peak around noon, dips in afternoon, declines toward bedtime

Chronotype shifts peak earlier (larks) or later (owls)

38
Q

What cognitive changes might you expect to see across someone’s lifespan?

A

Problem-solving peaks in 20s

Working memory ~30

Emotion perception 40s-60s

Comprehension/processing peak ~50 and stay high for decades