Week 1 Flashcards

1
Q

Define environmental toxicology

A

branch of tox that studies the effects of the exp of humans & other living things to chem’s in the environment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Define Ecotoxicology

A

branch of toxicology that studies the effects of the exposure of living organisms to chem’s in the environment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Risk = _____ + _____

A

Risk = Toxicity + Exposure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is risk mitigation?

A

actions taken to reduce the potential of risk, i.e. harm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Definition: any physical, chemical, biological, or radiological substance or matter that has an adverse effect on air, water, soil (or biota)

A

Contaminant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Definition: generally, any substance introduced into the environment that adversely affects the usefulness of a resource

A

Pollutant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Definition: Harmful to living organisms

A

Toxic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Definition: a chemical or mixture that may present an unreasonable risk of injury to health or the environment

A

Toxic Substance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Definition: Materials contaminating the environment that cause death, injury, disease, and/or birth defects in organisms that ingest or absorb them. The quantities and length of exposure necessary to cause these effects can vary widely

A

Toxic Pollutants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Definition: The degree of danger posed by a substance to animal or plant life

A

Toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the “big 3” chronic effects?

A

Survival, growth, and reproduction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Definition: severity of the effect is a fxn of the exposure (ie: dose or [ ]). Bigger dose = more severe effect. Threshold present.
(_______ effects)

A

Deterministic effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Definition: Probabilistic in nature. The likelihood, but not necessarily the severity of the effect is a fxn of the exposure (ie, dose or [ ]). Bigger dose = more likely an effect will occur. No threshold.
(_______ Effects)

A

Stochastic effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

These types of effects usually start at 96 hours or less; msrd effect usually death or lethality or mortality or survival (lack thereof)

A

Acute/short-term effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

These types of effects usually have lifetime exposure and a variety of effects

A

Chronic/long-term effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the diff b/w endpoint and effect?

A

Effect is the harmful, adverse effect you are LOOKING FOR

Endpoint is how much of it you want to MEASURE

17
Q

What are LC and LC50?

A

LC = lethal concentration

LC50 = [ ] lethal to 50% of the exposed population

18
Q

What are EC and EC50?

A

EC = Effects [ ]

EC50 = [ ] that produces the desired effect in 50% of the exposed pop’n

19
Q

What are LD and LD50?

A

LD = Lethal Dose

LD50 = Dose that is lethal to 50% of exposed pop’n

20
Q

What is the diff b/w a dose and a [ ] and what are the units?

A

[ ] = exposed in ambient environment (mg/L or mg/kg)

Dose - qty of a toxicant delivered inside the organism (mg/kg body weight)

21
Q

What do these acronyms stand for?

LEL, NEL, LOEL/LOEC, NOEL/NOEC, LOAEL, NOAEL, MATC

A

LEL - Lowest effects level
NEL - No effects level
LOEL/LOEC - lowest observed effects level OR [ ]
NOEL - No Observed Effects Level OR [ ]
LOAEL - Lowest observed adverse effects level
No observed adverse effects level
MATC - Maximum acceptable toxicant concentration

22
Q

How do you determine the MATC?

A

Geometric mean of the LOEC and NOEC (times them together & take the square root)

23
Q

What must be specified in order for the LC50 to have any meaning?

A

Duration of exposure must be specified

24
Q

What are 2 major classes of exposures?

A

Acute and chronic

25
Q

What are two acute effects?

A

death and immobilization

26
Q

Chemical A has an LC50 of 5mg/L and chemical B has an LC50 of 16mg/L. Which is more toxic?

A

Chemical A

27
Q

Which would result from an aquatic toxicity test with fish, a LOEL or a LOEC?

A

LOEC ???

28
Q

What 3 endpoints are statistically derived?

A

LC50, E50, and LD50

29
Q

What 3 factors are needed to describe exposure?

A

Duration, Magnitude, and Frequency

30
Q

What aspect of uptakes of pollutants requires ENERGY?

A

Active Transport

31
Q

What type of molecules can move through membranes by diffusion?

A

Neutral, lipophilic

32
Q

What type of organic compounds are usually lipophilic? Polar or non-polar?

A

Non-polar

33
Q

Which compound will pass through a membrane more easily; Compound A with a low Log Kow or compound B with a high Log Kow??

A

B

34
Q

What is significant about Xenobiotic molecules in regards to membranes?

A

They move through membrane pores

35
Q

Toxicity in sediments is affected by: (4)

A

Grain size, organic carbon content, acid volatile sulfides, and oxygen

36
Q

Name the Toxicity effects and give examples of toxins:
A. 1+1=0.5
B. 1+1=2
C. 1+1=5

A

A. Antagonistic: Cadmium + Zinc
B. Additive: PAHs
C. Synergistic: Copper Sulfate and Diquat

37
Q

What do these 3 acronyms stand for?
BTEX
PAHs
PCBs

A

BTEX = Benzene, Toluene, Ethylbenzene, and Xylene

PAHs = Polycyclic Aromatic Hydrocarbons

PCBs = Polychlorinated biphenyls