Week 1 Flashcards
What is the basic process of primary hyperalgesia after injury
Substance P and CGRP trigger synthesis of prostaglandins which sensitise the PAN
How could sympathetic NS activity trigger nociception?
Nociceptors have receptors for ATP and NA, which are both release by SNS activity
Prolonged activation of PAN leads to what?
Peripheral sensitisation
Sensitivity to what only occurs peripherally?
Heat
What three ascending tracts are associated with nociceptive transmission in the spinal cord
- Spinothalamic
- Spinomesencephalic
- Spinoparabrachial
Define Allodynia
A stimulus is perceived as painful before it would be in normal people
Define hyperalgesia
Pain onset occurs at the same point in which someone would normally experience pain, but a heightened pain response is felt
Central sensitisation = …
Wind up + long term potentiation
What is wind up ?
Dorsal horn neurons firing off more action potentials as a result of increased afferent C fibre activity
What is long term potentiation
Long term increases in excitatory synaptic transmission in the dorsal horn
How does the brain increase pain?
Reducing inhibition and increasing facilitation
How does the brain decrease pain?
By increasing inhibition and reducing facilitation
How can coupling between sympathetic fibres and PAN’s occur?
Sympathetic sprouting
In chronic post surgical or post traumatic pain, what is the most common pain type?
Neuropathic
Pain post stroke would be classified as what type of chronic pain?
Chronic central neuropathic pain
