Week 1 Flashcards
What is neuroscience?
scientific study of the nervous system, which controls behaviour
- interdisciplinary
- BPS fundamental
Central nervous system (CNS)
- brain
- spinal cord
Peripheral Nervous system (PNS)
Nerves (Cranial and spinal)
Ganglia (a mass of nerve cell bodies)
Neurones
Building block of the nervous system
- dendrite: receives the AP
- Myelin sheath - Insulates AP
- Nodes of Ranvier - where the AP travels (saltatory conduction)
Why is NS an essential subject to pscyhology?
Behaviour is initiated in the nervous system
Psychologists who study biological bases of behaviour name?
Behavioural neuroscience
History of neuroscience
1) historical notions
2) Evolution
3) brain evolution
1) Human prehistory (2.5 million years ago)
- stone age, bronze age, iron age, neolithic period
- blunt force cranial trauma (on right = effects left side of body = brain works counterlaterally)
- cranial trepanation
- “5-10% of all skulls found from the Neolithic period were trepanned with single or multiple skull openings of various sizes”
- Drilled holes in heads
○ Release of evil spirits?
○ Alleviation of pressure on brain?
Ancient Egypt
- Earliest written reference to the brain (17th Century BCE) – the Edwin Smith Surgical Papyrus - doctors of the brain used to operate on the brain and write their methods
- Believed the heart to be the control of function surprisingly
Body and most organs were preserved (mummified) after death… but not the brain
- Believed the heart to be the control of function surprisingly
Ancient Greece
- Hippocrates (c. 460-377 BCE) the theory of the four humours “… the source of our pleasure, merriment, laughter and amusement, as of our grief, pain, anxiety, and tears is none other than the brain” ‘father of medicine’
- Yellow bile, black bile, phlegm & blood = humours
= Acknowledges importance of brain - Aristotle (384-322 BCE) “… the brain is not responsible for any of the sensations at all, the correct view is that the sear and source of sensation is the region of the heart”
(Also Socrates & Plato)
- Yellow bile, black bile, phlegm & blood = humours
Roman Empire
Galen (130-200 CE)
- saw the brain as the ruling organ of the body
- Common sense, cognition and memory were all functions of the brain
- Discovery of ventricles fitted with Hippocrates’ theory of humourism
The dark ages (~500-1000 AD)
- Nothing documented
Beginning of christianity in western world
The Renaissance (3 significant people)
- Leonardo Da Vinci
- Andreas Vesalius
- Rene Descartes
Da Vinci (1452-1519)
- Sensation, cognition and memory attributed to the “3” ventricles
- Drawings of the brain, nervous system
Vesalius (1514-1564)
- Added more detail to the understanding of brain structure
Found errors in Galen’s anatomy (e.g. blood does not flow from the left to the right side of the heart)
Descartes (1596-1650)
- Fluid-mechanical theory of brain function
- Reflexive theory (realised reflex was not controlled by the brain)
- Dualism (the mind and the body are one, pineal gland - communicating with the ‘spirits and gods’ which then control the body)
‘ I think therefore I am’
The 19th Century: 4 key insights…
1) Nerves and Wires
2) Localisation of specific brain functions
3) the neuron
4) Evolution of the brain
Nerves are wires: Luigi Galvani (1737-1798)
- Stimulation of nerves in frogs caused muscle contractions
Major finding - an electrical process
Nerves are wires: Hermann von Helmholtz (1821-1894)
- Human physiology is subject to the laws of nature
- Measured the speed of nerve conduction
○ * ~90 ft/sec
○ * Slow – not just electrical, but physiological
e,g, used eals
- Measured the speed of nerve conduction
Localisation of specific brain functions: Johannes Müller (1801-1858)
- Proposed the “law of specific nerve energies”
- Neurones are the same but they go to different parts of the brain (e.g. optical vs auditory nerves)
Localisation: Marie-Jean-Pierre Flourens (1794 1867)
- Experimental ablations (electrical stimulation = knock out part of the brain)
= different effects all over the body of animals- Intellect = cerebral cortex
- Lower brain = vital bodily functions
- Cerebellum = coordination and motor control
Localisation: Paul Broca (1824-1880)
- Damage to left frontal cortex = difficulties in language production
- Broca’s region - language production
Localisation: Gustav Fritsch & Eduard Hitzig
- Muscle contractions contralateral to brain hemisphere
Nailed down & confirmed the contralateral workings of the brain - the left hemisphere controls the motor functioning of the right side of the body…)
- The neuron
- The basic functional unit of the brain
Camillo Golgi (1843-1926)
- Invented a new staining technique
- Propose “reticular theory”
○ Golgi staining/ golgi cell….
Santiago Ramón y Cajal (1852-1934)
- Worked out neural circuitry of many brain regions
- Propose the “neuron doctrine” - building blocks
- The basic functional unit of the brain, interconnected by chemical synapses (NTS)