Week 1

Question 1

Collagen Type I

Answer 1

“one”-bONE, tendONE
1. Bone
2. Tendon
3. Dentin
4. Skin
5. Cornea

Provides tensile strength

D/t covalent bonds between collagen NOT head to tail attachment

Question 2

Collagen Type II

Answer 2

“CarTWOlage”
1. Hyalin, elastic cartilage
2. Intervertebral disk
3. Vitreous body

Observed as fibrils-resistance to intermittent pressure

Question 3

Collagen Type III

Answer 3

3D for ED Type III
1. Reticular lamina of basement membrane
2. Blood vessels
3. Fetal skin

Supporting scaffold for specialized cells (adipocytes)

Question 4

Type IV

Answer 4

Beneath the “four” floor
1. Basement lamina
2. Binds to laminin

Question 5

Type V

Answer 5

1. Amnion/chorion in fetus
2. Muscle/tendon sheaths

NO banded fibrils

Question 6

What is Connective Tissue derived from?

Answer 6

Mesoderm

Question 7

Clearance=

Answer 7

rate of elim/plasma concentration

Question 8

Dosing rate=

Answer 8

rate of elim=clearance X TC/F (bioavail)

Question 9

t1/2=

Answer 9

0.693 X Vd/CL

Question 10

Vd=

Answer 10

Amt of drug in body/ plasma concentration

Question 11

Maintenance dose=

Answer 11

(DR/F) X DI

Question 12

Loading dose=

Answer 12

(Vd X TC)/F OR MD X AF

Accumlation Factor = 1/% lost in 1 dosing interval based on half lifes

Question 13

Css=

Answer 13

DR/CL

Question 14

Autosomal Recessive

Hardy Weinburg

Answer 14

q=square root I

Question 15

Autosomal Dominant

Hardy Weinburg

Answer 15

q=1/2 I

Question 16

X-Linked

Hardy Weinburg

Answer 16

q=I