Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Heme/Lymph > Wednesday Groupings/Definitions/Presentations > Flashcards

Wednesday Groupings/Definitions/Presentations Flashcards

1
Q

Lymphocytosis count

A

> 4000

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Lymphocytoses causes

A

infectious-EBV, CMV, hepatitis, etc

transient stress-trauma, MI, seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

List the 5 neoplastic proliferations of mature lymphocytes

A 
CLL
Hairy Cell Leukemia
Splenic marginal zone lymphoma
ATLL
Sezary syndrome
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

List the 7 lymphoid neoplasms we need to know

A 
B-ALL
T-ALL
CLL/SLL
Hairy Cell
Large Granular lymphocytic leukemia
Mycosis fungoides/Sezary syndrome
ATLL
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Name the precursor B-cell neoplasm

A

B-ALL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Name the 2 peripheral B-cell neoplasms

A

CLL/SLL

Hairy Cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Name the precursor T-cell neoplasm

A

T-ALL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Name the peripheral T-cell and NK-cell neoplasms

A

large granular lymphocytic leukemia
mycosis fungoides/sezary syndrome
Adult T-cell leukemia/lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Key features of B-ALL

A

precursor B cells
kids
pancytopenia
aggressive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Key features of T-ALL

A 
precursor T cells
adolescent males
thymic masses
aggressive
variable BM involvement
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Key features of hairy cell

A 
memory B cells
older males
pancytopenia
splenomegaly
indolent
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Key features of CLL/SLL

A 
naive B or memory B
older adults
BM, LN, spleen and liver disease
autoimmune hemolysis 
thrombocytopenia (minority)
indolent
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Key features of ATLL

A 
caused by HTLV-1 
helper T cells
adults with cutaneous lesions
BM involved
hypercalcemia
Japan, West Africa, Caribbean
aggressive (fatal months to a year)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Mycosis Fungoides/Sezary syndrome key features

A

helper t cells
adults
cutaneous patches/plaques/ etc
indolent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Large Granular lymphocytic leukemia

A 
cytotoxic T and NK cell types
RARE
adults
splenomegaly
neutropenia
anemia
sometimes with AI diseases (Rheumatologic)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

“starry sky appearance”

A

burkitt lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Are tumors with mutated or unmutated IG segments more aggresse?

A

those w/unmutated IG segments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is MBUS?

A

monoclonal B cells of undetermined significance

asymptomatic that have CD5+Bcells inthe PB but too few to be CLL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Are tumors with mutated or unmutated IG segments more aggresse?

A

those w/unmutated IG segments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is MBUS?

A

monoclonal B cells of undetermined significance

asymptomatic that have CD5+Bcells inthe PB but too few to be CLL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Factors the make CLL/SLL prognosis worse

A

11q/17p deletions
lack of somatic hypermutation
expression of ZAP70

22
Q

What does ZAP-70 do?

A

augments signals produced by the Ig receptor

23
Q

What is richter syndrome?

A

transformation from CLL/SLL to large B cell lymphoma/other more aggressive tumor

24
Q

Lab findings of hairy cell leukemia?

A

hairlike projections

BM can’t be aspirated “dry tap”

25
Q

Sezary syndrome blood smear finding?

A

Cerebriform nuclei

26
Q

What can HTLV-1 give rise to besides ATLL?

A

demyelinating disease of CNS and thoraco lumbar spinal cord

27
Q

What type of genetic material do all retroviruses contain?

A

2 copies of single stranded +RNA

28
Q

ATLL histology

A

flower cells

abnormally lobulated nuclei

29
Q

What is TSP/HAM? Cause

A

Tropic spastic paraparesis/HTLV_1 associated myelopathy

HTLV-1

30
Q

What is TSP/HAM? Cause

A

Tropic spastic paraparesis/HTLV_1 associated myelopathy

HTLV-1

31
Q

Multiple Myeloma Key features

A 
most common plasma cell neoplasm
malignant
osteolytic lesions/pathologic fractures
end organ damage
amyloidosis
32
Q

What types of end organ damage are seen in multiple myeloma?

A 
(CRAB)
hyperCalcemia
Renal insufficiency
Anema
Bone disease
33
Q

What are the most common locations for lytic bone lesions in multiple myeloma?

A 
vertebrae
ribs
skull
pelvis
femur
34
Q

What is rouleaux and when is it seen?

A

red cells coining up on top of each other because there’s too much protein around
seen in multiple myeloma

35
Q

Main complication of multiple myeloma? Cause of death?

A

immunosuppression

recurrent infections COD

36
Q

Multiple myeloma prognosis?

A

incurable

3yrs

37
Q

What is MGUS?

A

monoclonal gammopathy of undetermined significance

benign but, precursor to multiple myeloma

38
Q

What are plasmacytomas?

A

localized growth of monoclonal plasma cells

seen in Multiple Myeloma or as distinct entity

39
Q

Where are most common plasmacytomas as distinct entities located?

A

upper respiratory tract

40
Q

What is amyloid?

A

an extracellular proteinaceous misfolded substance

41
Q

What is amyloidosis? most common forms?

A

disease characterized by deposition of amyloid

amyloid light chain, amyloid associated, beta amyloid

42
Q

Lab finding for amyloidosis?

A

apple green birefringence on congo red stain

43
Q

What does Primary amyloidosis produce? causes?

A 
light chains (bence jones proteins)
plasma cell dyscrasia (MM or MGUS)
44
Q

What gene is on 17p?

A

p53

45
Q

Which age groups have worst prognosis with B-ALL?

A

<2

adults

46
Q

Good genetic prognostics for B-ALL

A

hyperdiploidy

t(12,21)

47
Q

Bad genetic prognostics for B-ALL

A

hypodiploidy

t(9,22)

48
Q

Bad clinical prognostics for B-ALL

A

100,000
CSF involvement
marrow involvement by day 15

49
Q

Good prognostic indicators CLL/SLL

A

mutated IG gene (post germinal)

deletion 13q

50
Q

Bad prognostic indicators CLL/SLL

A 
unmutated IG (pregerminal)
CD38/ZAP-70
deletion 11q, 17p
51
Q

List the causes of atypical lymphocytes +/- lymphocytoses

A 
CLL/SLL
Leukemic Lymphoma
Hairy Cell
ATLL
Sezary

Heme/Lymph (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions