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Heme/Lymph > Friday Groupings/Definitions/Presentations > Flashcards

Friday Groupings/Definitions/Presentations Flashcards

1
Q

Causes of follicular hyperplasia

A

RA
toxo
early HIV infection

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2
Q

Reactive vs neoplastic follicles

A

architecture preserved in reactive

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3
Q

What causes paracortical hyperplasia?

A

T-cell mediated responses

ie/mono

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4
Q

Sinus histiocytosis definition & cause

A

increase in number and size of cells in lymphatic sinusoids

in nodes draining carcinoma of the breast

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5
Q

List the peripheral B Cell Lymphomas

A 
lymphoplasmacytic lymphoma
splenic and nodal marginal zone lymphomas
extranodal marginal zone lymphoma
mantle cell lymphoma
follicular lymphoma
marginal zone lymphoma
diffuse large b cell lymphoma
burkitt lymphoma
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6
Q

List the Peripheral T cell and NK cell lympohoma

A

unspecified peripheral T cell lymphoma
anaplastic large cell lymphoma
extranodal nk/t-cell lymphoma

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7
Q

List the hodgkin lymphoma classical subtypes

A

nodular sclerosis
mixed cellularity
lymphocyte depletion

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8
Q

Other hodgkin lymphoma (non-classical)

A

lymphocyte predominance

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9
Q

Burkitt Lymphoma features

A 
germinal center B cell derived
African/Endemic & sporadic types
aggressive in those with HIV
adolescents or young adults with extranodal masses
EBV associated
aggressive
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10
Q

Diffuse large B cell lymphoma features

A 
germinal center B cell derived
usually adults
30% extranodal
aggressive
most common form of NHL
large cell size, diffuse growth pattern
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11
Q

Extranodal marginal zone lymphoma features

A

memory B cell
extranodal sites in adults with chronic inflammatory disease
may remain localized
indolent
may regress if inciting agent is eradicated

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12
Q

Follicular lymphoma features

A 
germinal center B cell
older adults
generalized lymphadenopathy + BM involvement
paratrabecular lymphoid aggregates
indolent
incurable
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13
Q

Mantle Cell Lymphoma features

A 
naive B cell
older males
20-40% w/PB involvement
disseminated disease
moderately aggressive
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14
Q

Peripheral T-cell lymphoma, unspecified, features

A

helper or cytotoxic T (mature)
older adults
usually lymphadenopathy
sometimes eosinophilia, pruritus, fever, wt loss
aggressive (worse prog than comp agg B cell neoplasms)
pleomorphic mixture of T cells

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15
Q

Anaplastic large cell lymphoma features

A 
cytotoxic T cell
children and young adults
lymph node & soft tissue disease
aggressive
"hallmark cells"-large anaplastic cells
very good prognosis
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16
Q

Extranodal NK/T-cell lymphoma features

A 
nk cell (common)
cytotoxic t cell (rare)
adults with destructive extranodal (esp nasopharyngeal) masses
usually sinusoidal
aggressive
associated with EBV
17
Q

What does follicular lymphoma transform to most often?

A

diffuse large B-cell lymphoma

18
Q

Burkitts histology

A

high mitotic index

starry sky pattern

19
Q

What does burkit’s lymphoma almost always fail to express? What does this result in?

A

BCL2

lack of apoptosis

20
Q

How does endemic burkitt present?

A

mass involving mandible

abdominal visceral-kidneys, ovaries, adrenals

21
Q

How does sporadic burkitt present?

A

mass involving the ileocecum and peritoneum

22
Q

Lymphoplasmacytic lymphoma features?

A

monoclonal IgM, can cause hyperviscosity syndrom known as waldenstroem macroglobulinemia
marrow with infiltrate of lymphocytes, plasma cells and plasmacytoid lympohcytes in varying proportions

23
Q

Mantle cell lymphoma prognosis?

A

3-4yrs

24
Q

Where are peripheral T and NK cell neoplasms most common?

A

Asia/Far east

25
Q

Hodgkin Lymphoma features

A

tumor giant cell-Reed Sternberg Cells (binucleate)
spread in stepwise fashion to anatomically contiguous nodes
Bcell origin

26
Q

What is the most common hodgkin lymphoma?

A

nodular sclerosis

27
Q

Nodular sclerosis Hodgkin features

A 
cervical, supraclavicular, mediastinal LNs
adolescents/young adults
prognosis excellent
lacunar cell
collagen bands
28
Q

Mixed-Cellularity Hodgkin Lymphoma

A

most comomn hodgkin in pts older than 50

Heme/Lymph (18 decks)

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