Friday Groupings/Definitions/Presentations Flashcards
Causes of follicular hyperplasia
RA
toxo
early HIV infection
Reactive vs neoplastic follicles
architecture preserved in reactive
What causes paracortical hyperplasia?
T-cell mediated responses
ie/mono
Sinus histiocytosis definition & cause
increase in number and size of cells in lymphatic sinusoids
in nodes draining carcinoma of the breast
List the peripheral B Cell Lymphomas
lymphoplasmacytic lymphoma splenic and nodal marginal zone lymphomas extranodal marginal zone lymphoma mantle cell lymphoma follicular lymphoma marginal zone lymphoma diffuse large b cell lymphoma burkitt lymphoma
List the Peripheral T cell and NK cell lympohoma
unspecified peripheral T cell lymphoma
anaplastic large cell lymphoma
extranodal nk/t-cell lymphoma
List the hodgkin lymphoma classical subtypes
nodular sclerosis
mixed cellularity
lymphocyte depletion
Other hodgkin lymphoma (non-classical)
lymphocyte predominance
Burkitt Lymphoma features
germinal center B cell derived African/Endemic & sporadic types aggressive in those with HIV adolescents or young adults with extranodal masses EBV associated aggressive
Diffuse large B cell lymphoma features
germinal center B cell derived usually adults 30% extranodal aggressive most common form of NHL large cell size, diffuse growth pattern
Extranodal marginal zone lymphoma features
memory B cell
extranodal sites in adults with chronic inflammatory disease
may remain localized
indolent
may regress if inciting agent is eradicated
Follicular lymphoma features
germinal center B cell older adults generalized lymphadenopathy + BM involvement paratrabecular lymphoid aggregates indolent incurable
Mantle Cell Lymphoma features
naive B cell older males 20-40% w/PB involvement disseminated disease moderately aggressive
Peripheral T-cell lymphoma, unspecified, features
helper or cytotoxic T (mature)
older adults
usually lymphadenopathy
sometimes eosinophilia, pruritus, fever, wt loss
aggressive (worse prog than comp agg B cell neoplasms)
pleomorphic mixture of T cells
Anaplastic large cell lymphoma features
cytotoxic T cell children and young adults lymph node & soft tissue disease aggressive "hallmark cells"-large anaplastic cells very good prognosis
Extranodal NK/T-cell lymphoma features
nk cell (common) cytotoxic t cell (rare) adults with destructive extranodal (esp nasopharyngeal) masses usually sinusoidal aggressive associated with EBV
What does follicular lymphoma transform to most often?
diffuse large B-cell lymphoma
Burkitts histology
high mitotic index
starry sky pattern
What does burkit’s lymphoma almost always fail to express? What does this result in?
BCL2
lack of apoptosis
How does endemic burkitt present?
mass involving mandible
abdominal visceral-kidneys, ovaries, adrenals
How does sporadic burkitt present?
mass involving the ileocecum and peritoneum
Lymphoplasmacytic lymphoma features?
monoclonal IgM, can cause hyperviscosity syndrom known as waldenstroem macroglobulinemia
marrow with infiltrate of lymphocytes, plasma cells and plasmacytoid lympohcytes in varying proportions
Mantle cell lymphoma prognosis?
3-4yrs
Where are peripheral T and NK cell neoplasms most common?
Asia/Far east
Hodgkin Lymphoma features
tumor giant cell-Reed Sternberg Cells (binucleate)
spread in stepwise fashion to anatomically contiguous nodes
Bcell origin
What is the most common hodgkin lymphoma?
nodular sclerosis
Nodular sclerosis Hodgkin features
cervical, supraclavicular, mediastinal LNs adolescents/young adults prognosis excellent lacunar cell collagen bands
Mixed-Cellularity Hodgkin Lymphoma
most comomn hodgkin in pts older than 50
