weakness Flashcards
DDX btw Duchenne and Becker’s muscle dystrophy
Duchenne’s: defective dystrophin, death by 15 yo
Becker’s: normal dystrophin, normal life span
difficulty raising from bent over position
- waddling gait
- absence of dystrophin
labs: elevated creatine kinase
duchenne muscular dystophy
- Muscle loss in LE
- toe walking
- female
- normal dystrophin
Becker’s muscle dystrophy
pop: female
- double vision, difficulty swallowing, weakness in the arms/ jaws with repeated use
- drooping eyelids
- slurred speech
myasthenia gravis
def: effects Cl- channels
made worst by:
- carbs
- alcohol
- exposure to cold
- stress
- rest after exercise
hypokalemia
def: defect of the Na+ channel gene on Chr. 17
made beter by:
- glucose
- insulin
- Ca+ gluconate
hyperkalemia
- limb oscillates as it approaches object
- titubation: gross tremor of head/ body that remits when lying down
- asterixis (liver flap): tremor ass. with hepatic encephalopathy
MS
amyloid plaque formation
alzheimer’s
child who just had a recent fever.
brief purposeless, involuntary movements of the distal ext. and face
sydenham’s sequella caused by Rheumatic fever
writhing movements of the prox limb
-due to: dopamergic overactivity in the basal gg
athetosis
- choreoform movements
- progressive intellectual and motor decline
huntington’s dz
bilateral leg weakness and distal paresthesia follwoing a viral infection
- protein in CSF
guillain-barre sx
M weakness and cramping in the hands
difficulty: dysphagia, chewing, coughing, or breathing
- combo of UMNL and LMNL
- atrophy, fasciculation and brisk DTRs
pop: football players
amyotrophic lateral sclerosis (ALS)
- lesion involving schwann cells and N fibroblasts
- multi hyperpigmented nodules
- cafe-au-lait lesions on trunk, pelvis, flexor creases of arms
-pop: peds
NF
