Wbcs Flashcards
Def neutropenia ? Dif of agranulocytosis? How do you know ?
-Decrease in granulocytes -severe neutropenia - patient total white blood count decrease up to 1000 and in some 200-300
Causes of neutropenia?
1-increase destruction or removal of neutrophils 2-inadequate or ineffective granulopoiesis
What cause is ineffective granulopoisis ?
-general bone marrow failure -Drugs -chemotherapy
Describe mechanism by which granulocytosis gets effected? ⬇️
Bone marrow failure? Due to aplastic anemia or leukemia Chemo therapy? Lead to transient marrow aplasia Drugs ? Affect granulcytic precursors
Give examples by witch neutrophils gets destroyed or removed rapidly??
1- some drugs (➕immune mediated injury) 2-splenomegaly 3-increase its use 4-idiopathic
How splenomegaly destroyed neutrophils ?
By sequestration and accelerated removal of neutrophils
How drugs decrease neutrophils??
It attack granulocytic precursors leading to isolated neutrophils
Morphology of neutropenia Describe
1- hyper cellular bone marrow 2-marked decrease in maturing granulocytic precursors in bone marrow
Why there is hypercellularity in bone marrow in neutropenia ?
Maybe due to increased neutrophils destruction Or due to megablatic anemia
In patients with neutropenia there is ⬆️ in infection specially in oropharynx. Explain how ?
Patient with neutropenia will have recurrent of infection that will lead to necrosis or ulcers lesions of oropharynx sites leading to massive microorganisms growth due to inability to mount leukocyte respond.
When we patent with neutropenia comes to you what you will see ?
أعراض الصخنه العاديه Chills Malaise Fevers Weakness Fatiguability
Eosinophilic Leukocytosis (Eosinophilia) Causes?
8 CVA Allergic disorders (asthma, hay fever) • Allergic skin diseases • Parasitic Infestations • Drug reactions • Certain malignancies • Collagenvascular disorders • Vasculitides • Atheroembolicdisease
Malignancy linked to eosinophilia?
(Hodgkin disease)
Allergic skin diseases linked to eosinophilia.
(pemphigus, dermatitis herpetiformis)
Causes of increased neutrophils?
Acute inflammation Sterile inflammation
Sterile inflammation Comes when
Happen with tissue necrosis such as myocardial infraction and burns لا يوجد عدوى فقط انسجه مايته
Basophilic Leukocytosis (Basophilia) Indicates what ?
indicative of a myeloproliferative disease) Rare
Malignancy related to basophilic leukocytosis
chronic myelogenous leukemia CML
Monocytosis causes “
ترم السي اه ياقلبي Chronic infections (TB) • Bacterial endocarditis • Rickettsiosis • Malaria • Collagen vascular diseases (SLE) • Inflammatory bowel diseases (ulcerative colitis
Lymphocytosis cause?
Chronic immunologic stimulation (T B, brucellosis) • Viral infections (hepatitis A,CMV, EBV, Bordetella pertussis )
Lymphocytes is usually increased with viruses but what other organisms can lead to its increase.(not viruses)
brucellosis TB Bordetella pertussis: whooping cough
