CLL /SLL

Question 1

CLL or SLL

Answer 1

Mature lymphocyte proliferation Mature morphology not functionally= immunologically incompent SLL ▶️ If less than 4000 or as a mass CLL▶️If more than 4000 or in blood

Question 2

Patient age and gender ( common)

Answer 2

Older than 60 male

Question 3

Pathogenisis

Answer 3

There is 🔼 level of BCL-2 This will lead to increase proliferation of cells ▶️ Immune dysregulation, accumulation of CLL/SLL cells suppresses normal B cell function

Question 4

Clinical presentation

Answer 4

Usually asymptotic

But Patient may develop:

• lymphocytosis ( if alone this is stage 1)
• General lymphadenopathy
• hepatosplenomegaly
• anemia and thrombocytopenia ( this indicates severity of the case )
• Hypogammaglobulinemia in more than 50٪؜ of patients (usually comes late ) lead to increase infection نقص تكون الانتيبوديز

Question 5

Morphology

Answer 5

• Sheets of small lymphocytes
• scattered ill defined foci of ▶️ larger لكن للان صغيرةactively dividing cells diffusely efface the involved lymph nodes (represents proliferation centers)
• Cells: Small lymphoid tumor cells

Nucleus : -round small -smooth nuclear membrane and prominent -central nucleoli

Question 6

Neoplastic cells have surface markers mention them .

Answer 6

5 ,23 بأورام البي سيل :⚡️5 مهم هذا لان مب موجود الا هنا والمينتيل ليمفوما 19 ,20 ,22

Question 7

Neoplastic cells have chromosomal abnormalities meantion them .

Answer 7

Trisomy 13 الأشهر Monosomy 11 13 17

Question 8

Prognosis

Answer 8

يعتبر indolent lymphoma

بعد التشخيص اغلب المرضى يعيشون اكثر من عشر سنين ويموتون من سبب ماله علاقه بالتشخيص