Hypersenitivity

Question 1

Example of atopic reaction

Answer 1

Hay fever Asthma Food allergy Eczema

Question 2

Anaphylactic presentations

Answer 2

It is related to the whole system Urticaria Skin erythema Itching Bronochoconstrication Laryngeal edema

Question 3

Clinical pathological manifestation hypersensitivity 1?

Answer 3

Immediate phase : start in 5 to 30 minutes and last for 60 minutes proximally 1- vasodilation 2-vascular leakage 3-smooth muscle spasms Late phase: start after 2-8 hours and last for days 1- inflammation and tissue destruction due to cytokines

Question 4

Hypersensitivity 2 pathognisis

Answer 4

Ab bind to Ag that can be on cell surface of ECM or drug. Ab binding to Ag will lead to pathology in 3 ways. 1-opensention 2-inflammation 3-Ab mediated cellular destruction

Question 5

Examples for each one ???

Answer 5

1- blood transfusions Agranulocytosis Thrombocytopenia أم كلثوم erythroblastosis fetalis Hemolytic anemia of newborns 2-good pasture syndrome glomerulonephritis vascular rejection 3- Mysethena gravis DM2 Graves

Question 6

Hypersensitivity 4

Answer 6

It’s delayed type (takes 2-3 days ) of hypersensitivity mediated by T cells هنا فيه ردة فعل مناعيه ( هنا رده الفعل هي خلايا التي سيلس )من الجسم اتجاه مواد يتعرض له الجلد أو باي مكان ثاني ولان هذا المواد تقعد وقت طويل أو انه مجرد ما هي تنشط خلايا التي سيل راح تسبب ضرر للأنسجة اللي هي متواجدة به .

Question 7

Hypersensitivity 4 morphology

Answer 7

-Cuffing look: peri vascular accumulation of mononuclear cells ( Th cells and macrophages ) -granuloma If antigen persist

Question 8

Th mediated hypersensitivity examples

Answer 8

6

1- IBD 2- MS 3-RA 4-Contact dermatitis 5-Tuberculin test

Question 9

Explain how contact dermatitis happen ?

Answer 9

Question 10

Explain how tuberculin test works ?

Answer 10

-

Question 11

Examples of CD8 mediated pathology ?

Answer 11

-graft rejection -DM1 -viruses

Question 12

Explain how CD 4 and CD8 mediate

Answer 12