HOD Lymphoma Flashcards
Witch types has increased eosinophils???
Mixed cellularity
Presentation of hod lymphoma
1-pain induced by alcohol
2-LAD
3-B symptoms : fever wight loss night sweatshirts
In case of depleted lymphocytes type patient comes with sub diaphragmatic organomegaly or disease
Reed strenberg cell is multi nucleated cell resembles owls eye
In witch type of lymphoma it is seen ?
hodgkin lymphoma
Morphology of lymphocytes predominant morphology
Lympohistocytic RS cells
Popped corn ; pop corn express B cell markers and fail to express 15, 30
Typical RS cells is rare
Reactive inflammatory cells are : scanty or absent (neutrophils, plasma, eosinophils)
Normal CDs-expressed of normal B and T cells ?
T cell 3458
B cell 19 , 20 , 22
RS expressed markers
15,30 positive
45 negative
Lymphocytes depleted morphology?
As name applied
Theres is few lymphocytes
RS cells Are dominance
Classification of hod lymphoma?
-Classical : ⬆️⬇️نمل Nodular sclerosis Mixed cellularity Lymphocytes rich Lymphocytes depleted -Non classical: Predominant lymphocytes lymphoma
Witch viruses increase risk for Hod lymphoma?
HIV
EBV (mononucleosis infections)
Witch lymph node are involved in HOD lymphoma
In general :
Mediastinal lymphadenopathy
Witch found in between sternum and spinal cord
In nodular sclerosis:
Lower cervical
Mediastinal
EBV lead to displacement of TS protein.
Explain the results of this effect?
It will lead to purposeless proliferation of Infected B cell (CD8)
HOD Lymphoma common in young adults or adolescents?
Nodular sclerosis
EBV lead to up regulation of kappa B nuclear transcription factor.
Explain this effect
Up regulation of this factor lead to increased activation of B lymphocytes.
This may play a role in allowing survival of B cell.
It act as anti apoptotic Genes regulator
type of HOD lymphoma poor in its outcome?
Depleted lymphocytes
Most patient comes with stage 3 or 4
Mixed cellularity morphology
These plenty of RS cells
Cellular infiltrate: plasma, small lymphocytes, macrophages, eosinophils
Type of HOD lymphoma common in old aged(older than50)
Mixed cellularity
Hod lymphoma consists of neoplasms cells and reactive inflammatory cells (non neoplasm)
Explain who they form ?
Causes: cytokines
IL-5
TGF-B
Morphology of nodular sclerosis?
Sclerosis: ثالث حرف ال يدل على لايكنورا سيلس والكلمه كله ان فيه كولاجين باندز
Sclerosis = fibrosis (collagen) band
Nodular: lacunar cells and collagen bands appear as nodular masses in lymphoid tissue
Explain how EBV lead to HOD lymphoma ???
By two ways:
1-up-regulation of factor kappa B
2-displace retinoblastoma (TS) protein
