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WBC Disorders > WBC Part 8 > Flashcards

WBC Part 8 Flashcards

1
Q

splenomegaly presents with what

A

left upper quadrant dragging sensation

discomfort after eating

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2
Q

nonspecific acute splenitis can occur in what and is characterized by what

A

any blood borne infections

enlarged spleen with softness and congestion of red pulp

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3
Q

congestive splenomegaly has what kind of etiology

A

intrahepatic etiology and extra hepatic etiology

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4
Q

Intrahepatic congestive splenomegaly is due to what

A 
right heart failure
hepatic cirrhosis (alcoholic and chronic hepatitis)
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5
Q

extrahepatic congestive splenomegaly is due to what

A

spontaneous portal vein thrombosis

splenic vein thrombosis

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6
Q

what happens to degree of firmness in splenomegaly

A

increases over time due to less efficient passage of the blood
means more time for the macrophages to destroy cells

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7
Q

increased pressure in splenomegaly results in what

A

intraparenchymal hemorrhage

Gandy-Gamma bodies

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8
Q

Gandy-gamma bodies are what and seen in what

A

deposition of pigment and cellular waste such as iron and calcium
seen in splenomegaly

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9
Q

splenic infarcts are due to what

A

sterile or infectious emboli

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10
Q

what do splenic infarcts look like

A

pale, wedge shaped and subcapsular in location

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11
Q

splenic infarcts are common in what

A

enlarged spleens

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12
Q

what neoplasms are associated with the spleen

A

hairy cell leukemia
non hodgkin lymphomas
hodgkin lymphoma

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13
Q

splenic rupture is usually due to what

A

usually precipitated by trauma
infectious mononucleosis
lymphoid neoplasm
massive, rapid, intraperitoneal hemorrhage

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14
Q

what developmental disorder of the thymus exist

A

hypoplasia (DiGeorge Syndrome)

Cysts (Benign but can be associated with neoplasms)

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15
Q

thymic hyperplasia refers to what

A

appearance of secondary follicles (Bcells)

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16
Q

thymic hyperplasia is associated with what conditions

A 
Myasthenia gravis
Graves disease
SLE
RA
other autoimmune disorders
17
Q

Thymoma (definition)

A

tumors of thymic epithelial cells with a background of immature t cells

18
Q

thymomas have what pathology

A

anterior superior mediastinum of adults
firm gray-white mass up to 20cm in size
areas of cystic necrosis and calcification
mixture of epithelial cells and non-neoplastic lymphocytes

19
Q

what are the categories of thymomas

A

benign encapsulated

malignant- cytologically benign (but invasive) or cytologically malignant (squamous cell carcinoma)

20
Q

what clinical features are seen in thymomas

A

impingement on mediastinal structures

association with myasthenia gravis

21
Q

Histiocytosis (define)

A

umbrella term for reactive process composed of macrophages and/or dendritic cells

22
Q

pulmonary langerhans histiocytosis is seen in what patients

A

smokers

spontaneous regression with cessation

23
Q

Birbeck granules are what and seen in what

A

tennis rackets seen on EM

langerhans cell histiocytosis tumor cells

24
Q

Langerhans cell histiocytosis tumor cells express what

A

S-100 and CD1a

25
Q

MM-LCH (multifocal, multisystem langerhans cell histiocytosis) is seen in what age patients

A

children under 2

26
Q

Letterer-Siwe disease is associated with what

A

MM-LCH (multifocal, multisystem langerhans cell histiocytosis)

27
Q

MM-LCH (multifocal, multisystem langerhans cell histiocytosis) presents with what

A

cutaneous lesions which look like seborrheic eruptions (trunk and scalp)
concurrent hepatospleomegaly, lymphadenopathy, pulmonary, lesions, and destructive bony tissues

28
Q

U&MU-LCH (unifocal and multifocal unisystem langerhans cell histiocytes) are

A

expanding erosive accumulation of neoplastic cells with medullary cavity of the bones (calvarium, ribs, femur most common)

29
Q

Eosinophilic granuloma is a term given to what

A

lesions of U&MU-LCH (unifocal and multifocal unisystem langerhans cell histiocytes)

30
Q

unifocal and multifocal U&MU-LCH (unifocal and multifocal unisystem langerhans cell histiocytes) occur at what ages

A

unifocal- children and adults

multifocal- young kids

31
Q

Hand-Schuller-Christian triad is associated with what

A

multifocal U&MU-LCH (unifocal and multifocal unisystem langerhans cell histiocytes)

32
Q

what is the Hand-Schuller-Christian triad

A

calvarial bone defect
diabetes insipidus
exophthalmos

WBC Disorders (8 decks)

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