WBC Part 8 Flashcards
splenomegaly presents with what
left upper quadrant dragging sensation
discomfort after eating
nonspecific acute splenitis can occur in what and is characterized by what
any blood borne infections
enlarged spleen with softness and congestion of red pulp
congestive splenomegaly has what kind of etiology
intrahepatic etiology and extra hepatic etiology
Intrahepatic congestive splenomegaly is due to what
right heart failure hepatic cirrhosis (alcoholic and chronic hepatitis)
extrahepatic congestive splenomegaly is due to what
spontaneous portal vein thrombosis
splenic vein thrombosis
what happens to degree of firmness in splenomegaly
increases over time due to less efficient passage of the blood
means more time for the macrophages to destroy cells
increased pressure in splenomegaly results in what
intraparenchymal hemorrhage
Gandy-Gamma bodies
Gandy-gamma bodies are what and seen in what
deposition of pigment and cellular waste such as iron and calcium
seen in splenomegaly
splenic infarcts are due to what
sterile or infectious emboli
what do splenic infarcts look like
pale, wedge shaped and subcapsular in location
splenic infarcts are common in what
enlarged spleens
what neoplasms are associated with the spleen
hairy cell leukemia
non hodgkin lymphomas
hodgkin lymphoma
splenic rupture is usually due to what
usually precipitated by trauma
infectious mononucleosis
lymphoid neoplasm
massive, rapid, intraperitoneal hemorrhage
what developmental disorder of the thymus exist
hypoplasia (DiGeorge Syndrome)
Cysts (Benign but can be associated with neoplasms)
thymic hyperplasia refers to what
appearance of secondary follicles (Bcells)
thymic hyperplasia is associated with what conditions
Myasthenia gravis Graves disease SLE RA other autoimmune disorders
Thymoma (definition)
tumors of thymic epithelial cells with a background of immature t cells
thymomas have what pathology
anterior superior mediastinum of adults
firm gray-white mass up to 20cm in size
areas of cystic necrosis and calcification
mixture of epithelial cells and non-neoplastic lymphocytes
what are the categories of thymomas
benign encapsulated
malignant- cytologically benign (but invasive) or cytologically malignant (squamous cell carcinoma)
what clinical features are seen in thymomas
impingement on mediastinal structures
association with myasthenia gravis
Histiocytosis (define)
umbrella term for reactive process composed of macrophages and/or dendritic cells
pulmonary langerhans histiocytosis is seen in what patients
smokers
spontaneous regression with cessation
Birbeck granules are what and seen in what
tennis rackets seen on EM
langerhans cell histiocytosis tumor cells
Langerhans cell histiocytosis tumor cells express what
S-100 and CD1a
MM-LCH (multifocal, multisystem langerhans cell histiocytosis) is seen in what age patients
children under 2
Letterer-Siwe disease is associated with what
MM-LCH (multifocal, multisystem langerhans cell histiocytosis)
MM-LCH (multifocal, multisystem langerhans cell histiocytosis) presents with what
cutaneous lesions which look like seborrheic eruptions (trunk and scalp)
concurrent hepatospleomegaly, lymphadenopathy, pulmonary, lesions, and destructive bony tissues
U&MU-LCH (unifocal and multifocal unisystem langerhans cell histiocytes) are
expanding erosive accumulation of neoplastic cells with medullary cavity of the bones (calvarium, ribs, femur most common)
Eosinophilic granuloma is a term given to what
lesions of U&MU-LCH (unifocal and multifocal unisystem langerhans cell histiocytes)
unifocal and multifocal U&MU-LCH (unifocal and multifocal unisystem langerhans cell histiocytes) occur at what ages
unifocal- children and adults
multifocal- young kids
Hand-Schuller-Christian triad is associated with what
multifocal U&MU-LCH (unifocal and multifocal unisystem langerhans cell histiocytes)
what is the Hand-Schuller-Christian triad
calvarial bone defect
diabetes insipidus
exophthalmos
