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WBC Disorders > WBC Part 1 > Flashcards

WBC Part 1 Flashcards

1
Q

t(14;18) is associated with what cancer and oncogene

A

follicular lymphoma

blc-2

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2
Q

t(8;14) is associated with what cancer and oncogene

A

burkitt lymphoma

c-myc

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3
Q

t(11;14) is associated with what cancer and oncogene

A

mantel cell lymphoma

Cyclin-D1

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4
Q

t(15;17) is associated with what cancer

A

acute promyelocytic leukemia

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5
Q

t(9;22) is associated with what cancer and oncogene

A

Chronic Myelogenous Leukemia (CML)

BRC-ABL (Philadelphia chromosome)

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6
Q

HHV8 virus is associated with what cancer

A

Pleural Effusion Lymphoma

Kaposi sarcoma

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7
Q

HTLV-1 virus is associated with what cancer

A

Adult T Cell leukemia/lymphoma

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8
Q

H. Pylori is associated with what cancer

A

Marginal Zone Lymphoma (MZL) MALT lymphomas of stomach

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9
Q

Hashimotos’s thyroiditis is associated with what cancer

A

Marginal Zone Lymphoma (MZL) aka MALT lymphoma of the thyroid

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10
Q

lymphadenopathy (define)

A

lymph node enlargement (tender or non-tender)

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11
Q

lymphadenitis (define)

A

lymph node inflammation (typically tender)

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12
Q

what causes follicular hyperplasia

A

stimuli that stimulate B cells

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13
Q

in follicular hyperplasia what does the mantle zone look like

A

polarized

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14
Q

describe 2 main characteristics of follicular hyperplasia seen on histological slide

A

tingible body macrophages
polar mantle region around germinal center
lots of follicles

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15
Q

describe bcl-2 staining in follicular hyperplasia and lymphoma

A

follicular hyperplasia- mantle stains and not germinal center (light germinal center
follicular lymphoma- follicle stains

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16
Q

paracortical hyperplasia is due to what

A

stimuli that stimulate cellular immune response (T-cell expansion)

17
Q

sinus histiocytosis is what and found where

A

numerous macrophages within sinuses

prominent in nodes draining cancer

18
Q

Acute Nonspecific lymphadenitis is characterized by what?

A

enlarges, red, tender, soft nodes

follicular hyperplasia

19
Q

What is acute nonspecific lymphadenitis due to

A

drainage of infections (localized or systemic)

20
Q

acute nonspecific lymphadenitis in the cervical lymph nodes is probably due to what

A

infections of teeth or tonsils

21
Q

acute nonspecific lymphadenitis in the axillary/inguinal lymph nodes is probably due to what

A

infections in the extremities or groin

22
Q

acute nonspecific lymphadenitis in the mesenteric lymph nodes is probably due to what

A

appendicitis or yersinia

23
Q

chronic nonspecific lymphadenitis is characterized by and due to what

A

non-tender nodes

due to chronic immunologic stimulation

24
Q

WBC cancer involving mostly tissue

A

lymphoma

25
Q

WBC cancer involving mostly blood/bone marrow

A

leukemia

26
Q

lymphoma patients clinically present with what

A

2/3 present with non-tender adenopathy

1/3 present with extra nodal tissue involvement

27
Q

leukemia patients clinically present with what

A

bone marrow failure symptoms

can involve liver or spleen

28
Q

EBV is associated with what cancers

A

Burkitt lymphoma
Hodgkin lymphoma
immunodeficiency associated B cell lymphomas
rare NK cell lymphomas

29
Q

what things cause follicular hyperplasia

A

toxoplasmosis (infections)
early HIV
non-specific

30
Q

what are B-symtoms

A

fever, night sweats, and weight loss

31
Q

80-85% of lymphoproliferative processes are of what origin

A

B-cell

32
Q

what cancer is associated with downs syndrome in children under 5 years of age

A

Acute Megakaryoblastic Leukemia

33
Q

what cancer is associated with downs syndrome in children over 5 years of age

A

Acute Lymphocytic Leukemia

34
Q

the blasts of acute leukemia’s have what nuclear characteristic when observed

A

punched out nucleoli

WBC Disorders (8 decks)

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