WBC Part 1 Flashcards
t(14;18) is associated with what cancer and oncogene
follicular lymphoma
blc-2
t(8;14) is associated with what cancer and oncogene
burkitt lymphoma
c-myc
t(11;14) is associated with what cancer and oncogene
mantel cell lymphoma
Cyclin-D1
t(15;17) is associated with what cancer
acute promyelocytic leukemia
t(9;22) is associated with what cancer and oncogene
Chronic Myelogenous Leukemia (CML)
BRC-ABL (Philadelphia chromosome)
HHV8 virus is associated with what cancer
Pleural Effusion Lymphoma
Kaposi sarcoma
HTLV-1 virus is associated with what cancer
Adult T Cell leukemia/lymphoma
H. Pylori is associated with what cancer
Marginal Zone Lymphoma (MZL) MALT lymphomas of stomach
Hashimotos’s thyroiditis is associated with what cancer
Marginal Zone Lymphoma (MZL) aka MALT lymphoma of the thyroid
lymphadenopathy (define)
lymph node enlargement (tender or non-tender)
lymphadenitis (define)
lymph node inflammation (typically tender)
what causes follicular hyperplasia
stimuli that stimulate B cells
in follicular hyperplasia what does the mantle zone look like
polarized
describe 2 main characteristics of follicular hyperplasia seen on histological slide
tingible body macrophages
polar mantle region around germinal center
lots of follicles
describe bcl-2 staining in follicular hyperplasia and lymphoma
follicular hyperplasia- mantle stains and not germinal center (light germinal center
follicular lymphoma- follicle stains
paracortical hyperplasia is due to what
stimuli that stimulate cellular immune response (T-cell expansion)
sinus histiocytosis is what and found where
numerous macrophages within sinuses
prominent in nodes draining cancer
Acute Nonspecific lymphadenitis is characterized by what?
enlarges, red, tender, soft nodes
follicular hyperplasia
What is acute nonspecific lymphadenitis due to
drainage of infections (localized or systemic)
acute nonspecific lymphadenitis in the cervical lymph nodes is probably due to what
infections of teeth or tonsils
acute nonspecific lymphadenitis in the axillary/inguinal lymph nodes is probably due to what
infections in the extremities or groin
acute nonspecific lymphadenitis in the mesenteric lymph nodes is probably due to what
appendicitis or yersinia
chronic nonspecific lymphadenitis is characterized by and due to what
non-tender nodes
due to chronic immunologic stimulation
WBC cancer involving mostly tissue
lymphoma
WBC cancer involving mostly blood/bone marrow
leukemia
lymphoma patients clinically present with what
2/3 present with non-tender adenopathy
1/3 present with extra nodal tissue involvement
leukemia patients clinically present with what
bone marrow failure symptoms
can involve liver or spleen
EBV is associated with what cancers
Burkitt lymphoma
Hodgkin lymphoma
immunodeficiency associated B cell lymphomas
rare NK cell lymphomas
what things cause follicular hyperplasia
toxoplasmosis (infections)
early HIV
non-specific
what are B-symtoms
fever, night sweats, and weight loss
80-85% of lymphoproliferative processes are of what origin
B-cell
what cancer is associated with downs syndrome in children under 5 years of age
Acute Megakaryoblastic Leukemia
what cancer is associated with downs syndrome in children over 5 years of age
Acute Lymphocytic Leukemia
the blasts of acute leukemia’s have what nuclear characteristic when observed
punched out nucleoli
