WBC Disorders

Question 1

Toxic granulatiins, dohke bodies, cytoplasmic vacuoles seen in

Answer 1

Leukocytosis

Question 2

Lymphoid neoplasm

Answer 2

Tumors of B cells, T cells, and NK cells

Question 3

Myeloid neoplasams

Answer 3

Acute myeloid leukamias
Myelodysplastic syndrome
Myeloproliferative neoplasm

Question 4

Histiocytoses

Answer 4

Proliferative lesions of macrophages and dendritic cells

Question 5

Acute lymphoblastic leukemia(ALL)

Answer 5

Mostly BCells
Mutation in NOTCH 1 for TCell development
B cell mutation are PAX 5,TCF3, ETV6 AND RUNX1

Question 6

Chronic lymphocytic leukamia

Answer 6

Make predominance
Deletions in 13q14.3, 11q and 17p and trisomy 12q
Overexpression of antiapoptotic protein BCL2

Question 7

Smudge cells or disrupted tumor cells are seen in

Answer 7

Chronic lymphocytic leukemia

Question 8

Ritcher syndrome

Answer 8

Cll or sll transform into more aggressive tumor into diffuse large B cell lymphoma

Question 9

Indolent waxing and waning course seen in

Answer 9

Follicular lymphona
Involves chromosomal translocations involved in BCL2 gene of chromosome 18 and IGH locus on Chromosome 14

Question 10

Diffuse large b cell lymphoma

Answer 10

Treatment anti cd 20 (rutiximab)
Due to BCL 6 overexpression
Break point in bcl6 at chromosome 3q27
Most common type of non hodgkin lymphoma

Question 11

Burkitt lymphona

Answer 11

Translocations of MYC gene on chromosome 8

Question 12

Tingile body macrophages seen in

Answer 12

Burkitt lymphoma we can see as starry sky appearance

Question 13

Splenomegaly and pancytopenia seen in

Answer 13

Hairy cell leukemia and acute myeloid leukemia and in splenomegaly
Mutation in threonine kinase BRAF
DOWNSTREAM OF RAS IN MAPK SIGNALING

Question 14

Multilobed or clover leaf nuclei seen in

Answer 14

Adult TCell leukemia
Involves cd4+Tcrlls in adults infected by HTLV 1

Question 15

Involves CD4+ and involves skin with 3 types of phases

Answer 15

Mycosis fungoides
Patch phase
Plaque
Tumor phase

Question 16

Generalized exfoliative erythroderma

Answer 16

Sezary syndrom and sezary cells are seen
CCR 4 and CCR 10 CHEMOKINE RECEPTORS ARE SEEN

Question 17

Aggressive tumors respond to radiation but not to chemotherapy

Answer 17

Extranidal NK or T cell lynphona

Question 18

Plasma cell neoplasm which has moth eaten lytic lesions

Answer 18

Multiple myeloma
Rearrangement of IGH locus on chromosome 14q32 and MYC gene

Question 19

Multiple myeloma features

Answer 19

C-Hyoercalcemia
R-renal failure
A-Anemia
B- bony lesions

Question 20

Plasmablast, mott cells, russel bodies and dutcher bodies seen in

Answer 20

Multiple myeloma

Question 21

Auer rods and azurophilic granules seen in

Answer 21

Acute myeloid leukemia
AML t(15, 17)

Question 22

Chronic myeloid leukemia

Answer 22

Presence of BCR-ABL gene mutation on chromosome 22 and ABL gene on chromosome 9

Question 23

Mantle cell lymphoma

Answer 23

Chromosome 11,14 of cycling D1

Question 24

Anaplastic large cell lymphoma

Answer 24

ALK gene on chromosome 2p23
Horseshoe shaped nuclei identifying feature
RAS and Jak stat pathway mutation
Market CD30

Question 25

Felty syndrome triad seen in

Answer 25

Large granular lymphocytic leukemia
It’s rheumatoid arthritis, splenomegaly, neutropenia

Question 26

Waldenstrom macroglobulinemia seen in and this disease also called as hyperviscosity syndrome

Answer 26

Lymphoplasmacytic lympoma

Question 27

Lymphadenooathy and helatomegaly are absent in

Answer 27

Large granulae lymphoctic leukemia

Question 28

Ringed siderobkasts seen in

Answer 28

Myelodysplastic anemia

Question 29

Panmyelosis means and seen in

Answer 29

It’s means overproduction of all formed and wBC and platelets and seen in polycythemia vera

Question 30

Teardrop cells seen in

Answer 30

Primary myelofibrosis

Question 31

Macrophage activation syndrome

Answer 31

Hemophagocytic lymphohistiocytosis