RESTRICTIVE LUNG DISEASES

Question 1

Coal worker pneumoconiosis results in further diseases like

Answer 1

Anthracosis
Simple black lung disease
Progressive massive fibrosis
Complicate coal workers pneumoconiosis

Question 2

Silicosis is caused by and it’s further disease development

Answer 2

By silica or silicon dioxide
Associated with tuberculosis and 2 fold increase in risks of lung cancer

Question 3

Most common manifestation of asbestos

Answer 3

Pleural plaques

Question 4

Pulmonary alveolar Proteinosis(PAP)

Answer 4

Defects in pulmonary macrophages due to deficiency of granulocyte macrophage colony stimulating factor
Or
Accumulation of surfactant in intraalveolar and bronchiolar spaces

Question 5

Pap is charcterized by

Answer 5

Bilateral patchy asymmetrical pulmonary opacifications

Question 6

Surfactant dysfunction disorder causes

Answer 6

Mutation in atp binding casette protein number 3 (ABCA 3) it is autosomal recessive
Surfactant protein c autosomal dominant
Surfactant protein B autosomal recessive

Question 7

Hypersensitivity pneumonitis is caused by

Answer 7

Organic dust containing antigens such as spores fungi, animal protein or bacterial products

Question 8

Syndromes associated with hypersensitivity pneumonitis

Answer 8

Farmer lung by exposure to hay
Pigeon breeders lung by protein and excreta of birds
Humidifier or air conditioner lung by thermoohilic bacteria in heated water reservoir

Question 9

Feature to identify the hypersensitivity pneumonitis

Answer 9

Nonnecrotizing granuloma
Macrophage inflammatory protein 1 alpha and IL8
Increase in CD4 and CD8 t lymphocytes
Type 4 hypersensitivity

Question 10

Large collection of macrophage seen in airspaces in which disease

Answer 10

Desquamative interstitial pneumonia

Question 11

Dusty brown macrophages or smoker’s macrophages seen in

Answer 11

Respiratory brochiolitis