WBC Anomalies/Abnormalities Flashcards
The stain used to identify Downey cell.
Pyronine stain (red)
An abnormal reactive lymphocyte or virucyte with large cytoplasm than nucleus. Has pseudolobilations.
Downey cells
Related to Kissing disease or Acute IM and EBV.
Downey cells
A monocyte with a phagocytosed nucleus of a lymphocyte.
Tart cells
Tart cells are present in patients with?
Drug sensitivity
The affected organ of LE cells.
Kidney
The disease present having the LE cells.
Lupus erythematosus (autoimmune disease)
A phagocytic neutrophil with phagocytosed degenerative nuclear mass off another neutrophil.
L.E. Cells
Ferrata cell is associated with what disease?
Subacute bacterial endocarditis (SBE)
A abnormal lymphocyte with segmented/lobulated nucleus.
Rieder Cells
This disease is observed in Rieder cell abnormality.
Chronic Lymphocytic Leukemia (CLL)
A thin, thread like structure arising from the nucleus associated with Malignant abnormal changes.
Hairy Cell
Stain used to identify Hairy cell leukemia.
TRAP
Similar to plasma cell, except of no cartwheel chromatin pattern.
Turk irritation cell
Presence of 2 nucleus found in one cell.
Tuinning deformity
Associated disease in Tuinning deformity.
Pernicious anemia
Hyposegmentation described as “Pince-nez” or “Dumbbell shaped”.
Pelger-huet Anomaly
Pince-nez is a congenital failure that can be seen in leukemia on what kind of cell?
Neutrophil
A blue colored inclusions seen in cytoplasm having large vacuole.
Dohle Amato bodies
Thought to be remnants of Rough ER using Giemsa stain.
Dohle Amato Bodies
Dohle Inclusion is present with patients having?
Toxic conditions, severe infections, burns and Chemotherapy
Associated with Dwarfism or Gargoylism or Pfaunder hurler syndrome.
Alder Reilly Bodies
Coarse azurophilic granules seen in granulocytes most commonly in neutrophils. Inherited as recessive trait.
Alder Reilly Bodies
A sex chromatin of somatic cell (X-chromosome).
Barr Bodies
A knob like structure arising from the lobe of neutrophil. Exclusive to females “Sexing of PMN”.
Drum stick
Jordan’s Anomaly is commonly found in patients with?
Muscular dystrophy
A fat containing granule observed in granulocyte and monocyte.
Jordan’s Anomaly
Similar to Dohle bodies but usually seen with Giant platelets.
May Hegglin Anomaly
Characterized by the presence of Peroxidase + Dohle like bodies.
Chediak higashi syndrome
Stains used to identify Czediak Higashi Syndrome.
Sudan black B, Acid phosphatase, and Peroxidase +
Auer Rod is usually seen with patients having this disease.
Acute monocytic/myelocytic Leukemia
A rod like structure seen in cytoplasm of monoblast and myeloblast.
Auer bodies or Auer Rod
Platelets encricling the peripheral borders of neutrophil.
Platelet Satellitosis
An abnormal neutrophil with 5-10 lobes seen mostly in Pernicious Anemia(Macrocytic normochromic).
Hypersegmented Neutrophil
Thorn cell, Spur cell with 5-10 irreversible thorn like projections.
Acanthocytes
Disease associated in Acanthocytes.
Hemolyic anemia, Alcoholic cirrhosis, and abetalipoproteinemia
Reversible thorn like projections that increase when BUN increase.
Burr cell
Occur in RBC placed under hypertonic NaCl solution.
Echinocyte or Crenated RBC
Sausage shaped found in Pernicious Anemia or Hereditary Elliptocytosis.
Elliptocytes
With thin peripheral cell membrane found in Microangiopathic H.A.
Keratocyte or Blister cell
Round cells lacking central pallor related with Hereditary spherocytosis and Spectrin deficiency.
Spherocytes
Slitlike central area of palor seen in Alcoholism and Rh null disease.
Stomatocytes or Mouth cell
Helmet shaped. Fragmenting RBC, found in HA, severe burns, diffuse intravascular coagulation syndrome (DIC).
Schistocyte
Tear drop cell typically observed thalassemia, Myelofibrosis, and Pernicious anemia.
Dacrocyte
Similar to tear drop but with long tail.
Racket cell
Also known as codocyte, mexican hat cell , platycytes, leptocyte , Greek helmet cell , bull’s eye cell. Comes from the greek word “Kodon=bell”.
Target cell
A star like RBC seen in certain anemias.
Astrocytes or Stellar cell
Thin thread like structure in loop shape or figure of 8. Remnants of nuclear membrane (mitotic spindle).
Cabot rings
Observed in patients with Pernicious anemia and Lead poisoning. Stains reddish purple with wright’s stain.
Cabot rings
A small round darkly staining body, remnants of the nucleus seen in HA, PA and after splenectomy. (DNA)
Howell-Jolly bodies
A fine or coarse basophilic stipplings (ribosome) seen in RBC that normally loss upon cell maturation.Seen in Lead poisoning.
Basophilic Stippling
Non-heme iron deposits found in the RBC, usually Prussian blue positive. Seen in Plumbism and Sideroblastic anemia.
Pappenheimer bodies or Siderocytic granules
With one blunt pointed and protruding end hence appears as “Washington movement shaped” or “finger like projection”.
Hgb SC
