WBC Abnormalities: Lymphocytes

Question 1

Cloverleaf-like; CLL

Answer 1

Rieder Cells

Question 2

Formed in cases of:

1. Pressure on smear prep (Remedy: 22% bovine albumin)
2. CLL

Answer 2

Smudge Cells

Question 3

Remnant of Lymphocytes
Thumbrint appearance

Answer 3

Smudge Cells

Question 4

remnant of granulocytic cells; Netlike chromatic

Answer 4

Basket Cells

Question 5

Downey Cells:

Plasmacytoid Lymphocyte
Turks Irritation Cells

Answer 5

Foamy Appearance

Question 6

Downey Cells:

Type II: Infectious Mononucleosis

Answer 6

Fried egg/Flared Skirt

Question 7

Downy Cells:

Type III: Transformed Lymphocytes / Reticular Lymphocytes

Answer 7

Swiss cheese/moth-eaten appearance

Question 8

PLASMA CELLS:

Cytoplasm stains bright-red color ; deposits of AMORPHOUS matter

SEEN IN MULTIPLE MYELOMA

Answer 8

Flame cells

Question 9

PLASMA CELLS:

Cytoplasm completely filled with RUSSELL BODIES

Answer 9

Grape or MOTT CELLS

Question 10

MONOCYTE-MACROPHAGE DISORDERS:

Most common lysosomal lipid storage diseases

DEFICIENCY OF B-GLUCOCEREBROSIDASE (beta-glucosidase)

Answer 10

Gaucher’s disease

Question 11

MONOCYTE-MACROPHAGE DISORDERS:

Characterized with Wrinkled cytoplasm

Answer 11

Gaucher’s Disease

Question 12

MONOCYTE-MACROPHAGE DISORDERS:

Deficiency of enzyme that CLEAVES SPHINGOMYELIN

Pick Cell

Foamy appearance

Answer 12

Niemann-Pick Disease

Question 13

Stains positive with TRAP (Tartrate Resistant Acid Phosphatase)

Answer 13

Hair Cell Leukemia

Question 14

CD Markers for Hairy Cell Leukemia

Answer 14

CD 19,20,22

Question 15

With Cerebriform nucleus / “Brain-like”

Answer 15

Sezary Cell

Question 16

Seen in Patient’s with MYCOSIS FUNGOIDES

Answer 16

Sezary Cell