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HEMATOLOGY > WBC Abnormalities: Granulocytes > Flashcards

WBC Abnormalities: Granulocytes Flashcards

1
Q

Autosomal Dominant ; Hyposegmentation with Peanut/Dumble/Spectre

A

Pelger-Huet

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2
Q

Pelger-Huetn Homozygous pH

A

Round Nucleus

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3
Q

Pelger-Huet Heterozygous pH

A

2 Lobes; common

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4
Q

Seen in Myeloproliferative disorders (CML)
Acquired Hyposegmentation

A

Pseudo-Pelger-Huet Anomaly

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5
Q

Neutrophils with MORE THAN 5 LOBES

A

Hypersegmentation

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6
Q

Old segmented neutrophils

A

Pseudohypersegmentation

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7
Q

Hereditary Hypersegmentation

A

Undritz anomaly

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8
Q

Acquired Hypersegmentation

A

Vit.B12 deficiency/Folic Acid Deficiency

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9
Q

CYTOPLASMIC ABNORMALITIES (4)

A

Alder-Reilly
Auer Rods
May-Hegglin Inclusions
Toxic Granules

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10
Q

purple-red particles with MUCOPOLYSACCHARIDE

A

Alder-Reilly

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11
Q

Associated with Hunter’s, Hurler and Maroteaux-lamy type

RESEMBLES TOXIC GRANULES

A

Alder-Reilly

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12
Q

ABNORMAL LYSOSOMAL DEVELOPMENT

A

Chediak-Higashi Syndrome

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13
Q

Characterized with Albinism
Gigantic Platelets
Impaired Chemotaxis and Delayed Killing of ingested bacteria

A

Chediak-Higashi Syndrome

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14
Q

Differentiate Alder-Reilly Vs Toxic Granules

A

Alder-Reilly are found in MONOCYTES AND LYMPHOCYTES

Toxic Granules are found in NEUTROPHIL

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15
Q

Pink or Red Rod Shaped; Peroxidase Positive seen in MYELOID AND MONOCYTIC SERIES

A

Auer Rods

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16
Q

Mass of AUER RODS

A

Faggot Cells

17
Q

Seen in

  • M3: APL (Acute Promyelocyte Leukemia)
  • DIC
A

AUER RODS

18
Q

Seen in patient with Infections and Burns (3)

A

Toxic Granules
Toxic Vacuoles
Dohle Bodies

19
Q

Precipitation of MYOSIN
Giant Platelets
Resembles Dohle Bodies

A

May-Hegglin Inclusions

20
Q

Aggregates of Rough Endoplasmic Reticulum ; Light-blue staining On Wright’s stain smear

A

Dohle Bodies

21
Q

dark granulation, azurophilic (primary) granules

A

Toxic granules

22
Q

Neutrophils have poor directional motility ; normal random motility

A

Job Syndrome

23
Q

Abnormal Directional and Random Motility

A

Lazy Syndrome

24
Q

Unable to kill catalase (+) organism

A

Chronic Granulomatous Disease

25
Q

Impaired NADPH OXIDASE

A

Chronic Granulomatous Disease

26
Q

Test for CGD

A

Nitroblue Tetrazolium Dye Test

27
Q

Neutrophils w/Large Puple Homogenous round Inclusion ‘ Buffy Coat

A

LE cells

28
Q

Confused with LE cell

A

Tart Cell

HEMATOLOGY (7 decks)

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