RBC Abnormalities: Anisocytosis Flashcards
Anisocytosis refers to the RBC variation in
Cell size
an index of variation of cell volume; correlates with degree of anisocytosis
RDW (Red Cell Distribution Width)
RDW is expressed numerically with COEFFICIENT VARIATION PERCENTAGE; normal range of
11.5 - 14.5%
RDW is calculated by
(SD / Mean of RBC size distribution) x100
Normal sized RBC 6-8 um ;
MCV 80-100 fL
Normocytic RBC
Normocytic RBC are seen in patients with
AHA
Acute Blood Loss
Hemolytic Anemia
Aplastic Anemia
Characterized with Small RBC <6 um and MCV of <80 fL
Microcytic RBC
Microcytic RBC are seen in patient with
ATIS
Anemia of Chronic Inflammation
Thalassemia
Iron Deficiency Anemia
Sideroblastic Anemia
Characterized with >8 um RBC and MCV of >100 fL
Macrocytic RBC
Megaloblastic Anemia
Myelodysplastic Anemia
Bone Marrow Failure
Chronic Liver Disease
Reticulocytosis
are seen in anisocytic patien’s characterized with
Macrocytic Anemia