Warfarin (dabigatran)

Question 1

Oral anticoagulants inhibit … which inhibits the synthesis of factors …

Answer 1

• vitK epoxide reductase

- II, VII, IX & X

Question 2

Indications of warfarin (4)

Answer 2

• RHD
• thrombosis
• PE
• TIA

Question 3

Warfarin is given prophylactically in

Answer 3

Prosthetic valve

Question 4

Contraindications of warfarin (4)

Answer 4

• PREGNANCY
• PU
• severe hptn
• alcohol

Question 5

What must be checked regularly when taking warfarin

Answer 5

INR

Question 6

What juice should be avoided in warfarin

Answer 6

Cranberry juice

Question 7

Drugs that enhance anticoagulation (3)

Answer 7

• alcohol
• NSAIDs
• anti-arrhythmics

Question 8

BS Abx that enhance anticoagulation (8)

Answer 8

• ampicillin
• ciprofloxacin
• chloramphenicol
• co-trimoxazole
• erythromycin
• metronidazole
• olfoxacin
• sulphonamides

Question 9

Antifungals that enhance anticoagulation (4)

Answer 9

• fluconazole
• itraconazole
• ketoconazole
• miconazole

Question 10

Lipid-lowering agents that enhance anticoagulation (2)

Answer 10

• fibrates

- Simvastatin

Question 11

Ulcer healers that enhance anticoagulation (2)

Answer 11

• cimetidine

- omeprazole

Question 12

Antiepileptics that reduce anticoagulation (3)

Answer 12

• carbamazepine
• primidone
• phenytoin

Question 13

Antifungal that reduces anticoagulation

Answer 13

Griseofulvin

Question 14

Retinoids that reduce anticoagulation

Answer 14

Aciterin

Question 15

Antidepressant that reduces anticoagulation

Answer 15

St John’s Wort

Question 16

Other meds that reduce anticoagulation (2)

Answer 16

• vitK

- OCP