Simvastatin Flashcards
1
Q
Simvastatin is a competitive inhibitor of … which reduces the concentration of the intermediate … leading to the upregulation of … receptors. Overall lowering … levels
A
- HMG co-enzyme reductase
- mevalonate
- LDL
- cholesterol
2
Q
Overall effect of statins (2)
A
- — LDL cholesterol & triglycerides
- ++ HDL cholesterol
3
Q
Contraindications for Simvastatin
A
Active liver disease
4
Q
Side effects of statins
A
- myalgia
- myositis
- rhabdomyolysis
5
Q
Important drug interaction to be aware of when taking statins
A
Warfarin
6
Q
Excretion of Simvastatin
A
Faeces
