WARFARIN Flashcards
1
Q
Mechanism
A
Vitamin K antagonist
Indirect inhibition of II, VII, IX, X, Protein C and Protein S
2
Q
Monitoring
A
PT / INR
Target INR = 2.5 (2.0-3.0)
Target INR mechanical mitral valve = 3.0 (2.5-3.5)
3
Q
Half Life
A
36-42 hrs
4
Q
Elective Reversal
A
5 days
5
Q
Antidote
A
10 mg Vitamin K IV
PCC (octaplex) 80 mL IV / 2000 IU for INR 1.5-3.0
