HEPARIN

Question 1

Mechanism

Answer 1

Combines with anti thrombin
Inhibits IIa, Xa, IXa, XIa, XIIa

Question 2

Dosing

Answer 2

DVT PPX: 5000 U subcut q 12 h
STEMI: 60 U / kg bolus IV (max 4000 U) then 12 U / kg / hr, titrated to a partial thromboplastin time 1.5 - 2.5 x control
NSTEMI: 60 U / kg bolus IV (Max 4000 U) then 12 U / kg / hr (max 1000 U / hr)

Question 3

Half Life

Answer 3

60-90 min
Longer with SC

Question 4

Elective reversal

Answer 4

Discontinue 4 hours prior to planned procedure

Question 5

Antidote

Answer 5

1 mg Protamine per 100 units of unfractionated Heparin

Question 6

Monitoring

Answer 6

aPTT