LMWH Flashcards
1
Q
Mechanism
A
Combine with antithrombin
Inhibit Xa and IIa (Common Pathway)
2
Q
Monitoring
A
Not required
If needed, anti-Xa assay
Consider in:
CrCl <30
Weight < 40 kg
Weight > 100 kg
Pregnancy
3
Q
Half life
A
3-6 hours
Renally cleared, prolonged in renal failure
4
Q
Elective Reversal
A
Discontinue 12-24 hr prior to planned surgery depending on dose and renal clearance
5
Q
Antidote
A
PCC
6
Q
Clearance
A
Renal
