Warfarin

Question 1

Warfarin inhibits _________ which is responsible for converting inactive vitamin K to active vitamin K

Answer 1

vitamin K epoxide reductase complex 1 (VKOR c1)

Question 2

Vitamin K dependent factors blocked by Warfarin include?

Answer 2

1972
10, 9, 7, 2

Question 3

Why does heparin require a 36-72 hours to achieve therapeutic concentration.

Answer 3

The body stops producing new vitamin K dependent factor but continues to utilize its available supplies until they are depleted

Question 4

Emergent reversal of warfarin can be achieved with ?

Answer 4

1. FFP 2 units
2. Recombinant factor 7a
3. Prothrombin complex concentrate

Question 5

________ mg of vitamin K can be used to reverse Warfarin in non emergent, minor surgical procedures.

Answer 5

10-20mg

Question 6

Vitamin K deficiency leads to ________

Answer 6

Coagulopathy

Question 7

Antibiotic therapy may lead to vitamin K deficiency by?

Answer 7

Killing Gi flora reducing bacterial synthesis of vitamin K

Question 8

0.5-1mg IM of vitamin K is common in neonates because?

Answer 8

They do not have the intestinal flora that synthesizes vitamin K

Question 9

Another name for exogenously administered vitamin K is?

Answer 9

Phytonadione

Question 10

It takes _________ hrs to restore vitamin K dependent factors

Answer 10

4-8hrs for liver to make them